Phase-Contrast Radiography Enables Detection of Early Changes in Articular Cartilage in a Mouse Model of Osteoarthritis
DC Field | Value | Language |
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dc.contributor.author | Yoon, Joon Shik | - |
dc.contributor.author | Won, Sun Jae | - |
dc.contributor.author | Kim, Sei Joo | - |
dc.contributor.author | Hong, Suk Joo | - |
dc.contributor.author | Kim, Gui Sang | - |
dc.contributor.author | Kim, Jae Min | - |
dc.date.accessioned | 2021-09-04T14:00:53Z | - |
dc.date.available | 2021-09-04T14:00:53Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-08 | - |
dc.identifier.issn | 0894-9115 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/92941 | - |
dc.description.abstract | Objective The aim of this study was to investigate the potential of using phase-contrast radiography to detect early changes in articular cartilage in a mouse model of osteoarthritis. Design An iodoacetate-induced mouse model of osteoarthritis was used. Mice with iodoacetate-induced osteoarthritis were euthanized at 1 and 2 wks after injection. Specimens were obtained by sectioning mouse tissue into 5-mm-thick slices. Sections were examined using synchrotron x-rays from the 7B2 beamline at the Pohang Light Source. Magnified microradiographic images, obtained by phase-contrast radiography, were used to identify changes in articular cartilage and the subchondral bone. Results Refraction-enhanced phase-contrast radiography enabled detailed microscopic and macroscopic observation of articular cartilage by a noninvasive technique. Detailed microscopic images revealed partially damaged articular cartilage, containing an irregular trilaminar zone, at 1 wk after injection. At 2 wks after injection, a necrotic cleft was clearly visible, along with collapse of the trilaminar zones. Shrunken chondrocytes and chondrocyte clusters of variable sizes were also observed. Conclusions Phase-contrast radiography is a feasible technique for the early detection of osteoarthritis and is capable of detecting microstructural changes in articular cartilage. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | SYNCHROTRON-RADIATION | - |
dc.subject | RADIOLOGY | - |
dc.subject | IODOACETATE | - |
dc.subject | LIGHT | - |
dc.subject | BONE | - |
dc.title | Phase-Contrast Radiography Enables Detection of Early Changes in Articular Cartilage in a Mouse Model of Osteoarthritis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoon, Joon Shik | - |
dc.contributor.affiliatedAuthor | Hong, Suk Joo | - |
dc.identifier.doi | 10.1097/PHM.0000000000000232 | - |
dc.identifier.scopusid | 2-s2.0-84937512654 | - |
dc.identifier.wosid | 000358121900008 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, v.94, no.8, pp.644 - 648 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION | - |
dc.citation.title | AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION | - |
dc.citation.volume | 94 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 644 | - |
dc.citation.endPage | 648 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rehabilitation | - |
dc.relation.journalResearchArea | Sport Sciences | - |
dc.relation.journalWebOfScienceCategory | Rehabilitation | - |
dc.relation.journalWebOfScienceCategory | Sport Sciences | - |
dc.subject.keywordPlus | SYNCHROTRON-RADIATION | - |
dc.subject.keywordPlus | RADIOLOGY | - |
dc.subject.keywordPlus | IODOACETATE | - |
dc.subject.keywordPlus | LIGHT | - |
dc.subject.keywordPlus | BONE | - |
dc.subject.keywordAuthor | Animal Model | - |
dc.subject.keywordAuthor | Cartilage | - |
dc.subject.keywordAuthor | Osteoarthritis | - |
dc.subject.keywordAuthor | Phase-Contrast | - |
dc.subject.keywordAuthor | Tomography | - |
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