Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Piscroside C, a novel iridoid glycoside isolated from Pseudolysimachion rotundum var. subinegrum suppresses airway inflammation induced by cigarette smoke

Authors
Song, Hyuk-HwanShin, In-SikWoo, So YeunLee, Su UiSung, Min HeeRyu, Hyung WonKim, Doo-YoungAhn, Kyung-SeopLee, Hyeong-KyuLee, DonghoOh, Sei-Ryang
Issue Date
21-7월-2015
Publisher
ELSEVIER IRELAND LTD
Keywords
Pseudolysimachion rotundum var. subintegrum; Piscroside C; Cigarette smoke; Inflammation; NF-kappa B
Citation
JOURNAL OF ETHNOPHARMACOLOGY, v.170, pp.20 - 27
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF ETHNOPHARMACOLOGY
Volume
170
Start Page
20
End Page
27
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/92994
DOI
10.1016/j.jep.2015.04.043
ISSN
0378-8741
Abstract
Ethnopharmacological relevance: Pseudolysimachion rotundum var. subintegrum (Speedwell, Plantaginaceae) is used as a traditional herbal medicine for treating bronchitis, cough and asthma in Korea, China, Russia, and Europe. Aim of the study: In this study, we investigated the protective effects of the novel iridoid glycoside, piscroside C (compound 1) isolated from the methanolic extract of P. rotundum var. subintegrum against inflammatory responses using a cigarette smoke induced chronic obstructive pulmonary disease (COPD) and TNF-alpha-stimulated human airway epithelial NCI-H292 cells. Materials and methods: The novel iridoid glycoside piscroside C was isolated from the methanolic extract of P. rotundum var. subintegrum. The chemical structure was established by NMR, HRESIMS, and optical rotation. In in vivo experiment, the mice received 1 h of cigarette smoke for 3 days. Piscroside C was administered to mice by oral gavage I h before cigarette smoke exposure for 3 days. In in vitro experiment, we evaluated the effect of piscroside C on proinflammatory mediators in H292 cells stimulated with TNF-alpha. Results: Piscroside C significantly reduced the neutrophil influx, reactive oxygen species production, IL-6, TNF-alpha, and elastase activity in bronchoalveolar lavage fluid in COPD animals. In addition, piscroside C attenuated NF-kappa B and ha phosphorylation, leading to reduced recruitment of inflammatory cells into the lung tissue. Consistent with the results of in vivo experiment, piscroside C significantly inhibited the expression of inflammatory cytokines (IL-6, IL-8 and IL-10) by inhibiting NF-kappa B activation, as resulting decrease in the phosphorylation of IKK beta, I kappa B alpha and TAK1 in TNF-alpha-stimulated H292 cells. Conclusion: These findings indicate that piscroside C effectively inhibits inflammatory responses, which is an important process in the development of COPD through suppression of IKK/NF-kappa B activation. Our study suggest that piscroside C might represent a useful therapeutic for the treatment of inflammatory airway disease. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Plant Biotechnology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lee, Dong ho photo

Lee, Dong ho
식물생명공학과
Read more

Altmetrics

Total Views & Downloads

BROWSE