Polymorphisms in PRKCDBP, a Transcriptional Target of TNF-alpha, Are Associated With Inflammatory Bowel Disease in Korean
DC Field | Value | Language |
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dc.contributor.author | Kim, Jung-Wook | - |
dc.contributor.author | Lee, Chang Kyun | - |
dc.contributor.author | Kim, Hyo Jong | - |
dc.contributor.author | Shim, Jae-Jun | - |
dc.contributor.author | Jang, Jae Young | - |
dc.contributor.author | Dong, Seok Ho | - |
dc.contributor.author | Kim, Byung-Ho | - |
dc.contributor.author | Chang, Young Woon | - |
dc.contributor.author | Chi, Sung-Gil | - |
dc.date.accessioned | 2021-09-04T14:23:14Z | - |
dc.date.available | 2021-09-04T14:23:14Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2015-07 | - |
dc.identifier.issn | 1598-9100 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93053 | - |
dc.description.abstract | Background/Aims: Emerging data indicate that polymorphic sequence variations in the tumor necrosis factor alpha (TNF-a) gene may affect its production, and be associated with the risk of inflammatory bowel disease (IBD). PRKCDBP is a putative tumor suppressor gene and a transcriptional target of TNF-alpha. The aim of this case-control study is to explore the possible association of single nucleotide polymorphisms (SNPs) in PRKCDBP with the development of IBD in Koreans. Methods: Genotyping analysis of four SNPs of PRKCDBP [rs35301211 (G210A), rs11544766 (G237C), rs12294600 (C797T), and rs1051992 (T507C)] was performed on 170 ulcerative colitis (UC), 131 Crohn's disease (CD) patients, and 100 unrelated healthy controls using polymerase chain reaction and restriction fragment length polymorphism. Results: Heterozygous configuration of three SNPs (G210A, G237C, and C797T) was very rare in both patients and healthy controls. However, allele frequencies of the T507C SNP showed a significant difference between UC patients and controls (P=0.037). The CC genotype of the T507C SNP was identified in 46.6% (61 of 131) of CD and 49.4% (84 of 170) of UC patients, but only in 33.0% (33 of 100) of healthy controls. Furthermore, CC homozygosity was more prevalent than TC heterozygosity in both CD and UC patients versus controls (P=0.016; genderadjusted odds ratio [aOR], 2.16; 95% confidence interval [CI], 1.16-4.04 and P=0.009; aOR, 2.09; 95% CI, 1.193.64; respectively) Conclusions: Our results suggest that the T507C SNP in PRKCDBP, a TNF-alpha-inducible gene, might be associated with susceptibility to IBD (particularly UC) development in Koreans. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ASSOC STUDY INTESTINAL DISEASES | - |
dc.title | Polymorphisms in PRKCDBP, a Transcriptional Target of TNF-alpha, Are Associated With Inflammatory Bowel Disease in Korean | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chi, Sung-Gil | - |
dc.identifier.doi | 10.5217/ir.2015.13.3.242 | - |
dc.identifier.wosid | 000420073200010 | - |
dc.identifier.bibliographicCitation | INTESTINAL RESEARCH, v.13, no.3, pp.242 - 249 | - |
dc.relation.isPartOf | INTESTINAL RESEARCH | - |
dc.citation.title | INTESTINAL RESEARCH | - |
dc.citation.volume | 13 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 242 | - |
dc.citation.endPage | 249 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002014430 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordAuthor | PRKCDBP | - |
dc.subject.keywordAuthor | Polymorphisms | - |
dc.subject.keywordAuthor | single nucleotide | - |
dc.subject.keywordAuthor | Crohn disease | - |
dc.subject.keywordAuthor | Colitis | - |
dc.subject.keywordAuthor | ulcerative | - |
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