Polymorphisms in PRKCDBP, a Transcriptional Target of TNF-alpha, Are Associated With Inflammatory Bowel Disease in Korean
- Authors
- Kim, Jung-Wook; Lee, Chang Kyun; Kim, Hyo Jong; Shim, Jae-Jun; Jang, Jae Young; Dong, Seok Ho; Kim, Byung-Ho; Chang, Young Woon; Chi, Sung-Gil
- Issue Date
- 7월-2015
- Publisher
- KOREAN ASSOC STUDY INTESTINAL DISEASES
- Keywords
- PRKCDBP; Polymorphisms; single nucleotide; Crohn disease; Colitis; ulcerative
- Citation
- INTESTINAL RESEARCH, v.13, no.3, pp.242 - 249
- Indexed
- KCI
- Journal Title
- INTESTINAL RESEARCH
- Volume
- 13
- Number
- 3
- Start Page
- 242
- End Page
- 249
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/93053
- DOI
- 10.5217/ir.2015.13.3.242
- ISSN
- 1598-9100
- Abstract
- Background/Aims: Emerging data indicate that polymorphic sequence variations in the tumor necrosis factor alpha (TNF-a) gene may affect its production, and be associated with the risk of inflammatory bowel disease (IBD). PRKCDBP is a putative tumor suppressor gene and a transcriptional target of TNF-alpha. The aim of this case-control study is to explore the possible association of single nucleotide polymorphisms (SNPs) in PRKCDBP with the development of IBD in Koreans. Methods: Genotyping analysis of four SNPs of PRKCDBP [rs35301211 (G210A), rs11544766 (G237C), rs12294600 (C797T), and rs1051992 (T507C)] was performed on 170 ulcerative colitis (UC), 131 Crohn's disease (CD) patients, and 100 unrelated healthy controls using polymerase chain reaction and restriction fragment length polymorphism. Results: Heterozygous configuration of three SNPs (G210A, G237C, and C797T) was very rare in both patients and healthy controls. However, allele frequencies of the T507C SNP showed a significant difference between UC patients and controls (P=0.037). The CC genotype of the T507C SNP was identified in 46.6% (61 of 131) of CD and 49.4% (84 of 170) of UC patients, but only in 33.0% (33 of 100) of healthy controls. Furthermore, CC homozygosity was more prevalent than TC heterozygosity in both CD and UC patients versus controls (P=0.016; genderadjusted odds ratio [aOR], 2.16; 95% confidence interval [CI], 1.16-4.04 and P=0.009; aOR, 2.09; 95% CI, 1.193.64; respectively) Conclusions: Our results suggest that the T507C SNP in PRKCDBP, a TNF-alpha-inducible gene, might be associated with susceptibility to IBD (particularly UC) development in Koreans.
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