Effects of Cudrania tricuspidata Fruit Extract and Its Active Compound, 5,7,3 ',4 '-Tetrahydroxy-6,8-diprenylisoflavone, on the High-Affinity IgE Receptor-Mediated Activation of Syk in Mast Cells
- Authors
- Lee, Taehun; Kwon, Jaeyoung; Lee, Dongho; Mar, Woongchon
- Issue Date
- 10-6월-2015
- Publisher
- AMER CHEMICAL SOC
- Keywords
- 5,7,3 ' ,4 ' -tetrahydroxy-6,8-diprenylisoflavone; Cudrania tricuspidata; Fc epsilon RI; mast cell; Syk
- Citation
- JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.63, no.22, pp.5459 - 5467
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Volume
- 63
- Number
- 22
- Start Page
- 5459
- End Page
- 5467
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/93274
- DOI
- 10.1021/acs.jafc.5b00903
- ISSN
- 0021-8561
- Abstract
- Cudrania tricuspidata fruit extract contains a rich source of prenylated flavonoids with potential antiatherosclerotic, hepatoprotective, and anti-inflammatory properties. However, the effect of C. tricuspidata fruit extracts and its active compounds on the high-affinity IgE receptor (FceRI)-mediated signaling remains unknown. In the present study, the effect of methanol extract from the fruits of C. tricuspidata (MFC) and its active compound, 5,7,3',4'-tetrahydroxy-6,8-diprenylisoflavone (THDPI), on FceRI-mediated signaling in mast cells was investigated. MFC and THDPI suppressed mast cell degranulation and Ca2+ influx. MFC also interfered with IgE-FceRI interaction and decreased FceRI beta mRNA expression in mast cells. Furthermore, MFC and THDPI inhibited the phosphorylation of Syk, LAT, and PLC gamma and F-actin redistribution. These results indicate that MFC and its active compound, THDPI, inhibit mast cell activation through the inhibition of FceRI-mediated Syk activation, suggesting a therapeutic potential for controlling mast cell activation in inflammatory and/or allergic processes.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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