Organelle-selective di-(2-picolyl)amine-appended water-soluble fluorescent sensors for Cu(II): synthesis, photophysical and in vitro studies
DC Field | Value | Language |
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dc.contributor.author | Lee, Yun Hak | - |
dc.contributor.author | Verwilst, Peter | - |
dc.contributor.author | Park, Nayoung | - |
dc.contributor.author | Lee, Joung Hae | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.date.accessioned | 2021-09-04T15:27:31Z | - |
dc.date.available | 2021-09-04T15:27:31Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 1388-3127 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93367 | - |
dc.description.abstract | A novel water-soluble fluorescent naphthalimide derivative as a sensor for Cu(II) has been synthesized. The sensor, conjugated with DPA (as the Cu(II)-binding moiety) and TPP (as the mitochondrial-targeting moiety) was further decorated with a galactose unit at the fluorophore's terminal using the click reaction. Although confocal fluorescence imaging revealed that probe 1 was not localized in mitochondria, and was neither quenched under Cu-overloading conditions, probe 1 did exhibit a high selectivity for Cu(II) ions over various metal ions in HEPES-buffered solutions. Furthermore the fluorescence was dramatically quenched upon the addition 1 equivalent of Cu(II), and the response was stable in the range of pH 6-10. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | ENDOPLASMIC-RETICULUM | - |
dc.subject | CU2+ | - |
dc.subject | MITOCHONDRIA | - |
dc.subject | COPPER | - |
dc.subject | CELLS | - |
dc.subject | CHEMODOSIMETER | - |
dc.subject | NAPHTHALIMIDE | - |
dc.subject | STRATEGIES | - |
dc.subject | PROBE | - |
dc.title | Organelle-selective di-(2-picolyl)amine-appended water-soluble fluorescent sensors for Cu(II): synthesis, photophysical and in vitro studies | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1007/s10847-015-0482-2 | - |
dc.identifier.scopusid | 2-s2.0-84943413222 | - |
dc.identifier.wosid | 000357574900013 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, v.82, no.1-2, pp.109 - 116 | - |
dc.relation.isPartOf | JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | - |
dc.citation.title | JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | - |
dc.citation.volume | 82 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 109 | - |
dc.citation.endPage | 116 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM | - |
dc.subject.keywordPlus | CU2+ | - |
dc.subject.keywordPlus | MITOCHONDRIA | - |
dc.subject.keywordPlus | COPPER | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CHEMODOSIMETER | - |
dc.subject.keywordPlus | NAPHTHALIMIDE | - |
dc.subject.keywordPlus | STRATEGIES | - |
dc.subject.keywordPlus | PROBE | - |
dc.subject.keywordAuthor | Fluorescence | - |
dc.subject.keywordAuthor | Copper ions | - |
dc.subject.keywordAuthor | Cell-imaging | - |
dc.subject.keywordAuthor | Subcellular environment | - |
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