Organelle-selective di-(2-picolyl)amine-appended water-soluble fluorescent sensors for Cu(II): synthesis, photophysical and in vitro studies
- Authors
- Lee, Yun Hak; Verwilst, Peter; Park, Nayoung; Lee, Joung Hae; Kim, Jong Seung
- Issue Date
- 6월-2015
- Publisher
- SPRINGER
- Keywords
- Fluorescence; Copper ions; Cell-imaging; Subcellular environment
- Citation
- JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, v.82, no.1-2, pp.109 - 116
- Indexed
- SCOPUS
- Journal Title
- JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
- Volume
- 82
- Number
- 1-2
- Start Page
- 109
- End Page
- 116
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/93367
- DOI
- 10.1007/s10847-015-0482-2
- ISSN
- 1388-3127
- Abstract
- A novel water-soluble fluorescent naphthalimide derivative as a sensor for Cu(II) has been synthesized. The sensor, conjugated with DPA (as the Cu(II)-binding moiety) and TPP (as the mitochondrial-targeting moiety) was further decorated with a galactose unit at the fluorophore's terminal using the click reaction. Although confocal fluorescence imaging revealed that probe 1 was not localized in mitochondria, and was neither quenched under Cu-overloading conditions, probe 1 did exhibit a high selectivity for Cu(II) ions over various metal ions in HEPES-buffered solutions. Furthermore the fluorescence was dramatically quenched upon the addition 1 equivalent of Cu(II), and the response was stable in the range of pH 6-10.
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Collections - College of Science > Department of Chemistry > 1. Journal Articles
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