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Simple Methods for Tracking Stem Cells with Cu-64-Labeled DOTA-hexadecyl-benzoate
- Authors
- Kim, Min Hwan; Woo, Sang-Keun; Kim, Kwang Il; Lee, Tae Sup; Kim, Chan Wha; Kang, Joo Hyun; Kim, Byung Il; Lim, Sang Moo; Lee, Kyo Chul; Lee, Yong Jin
- Issue Date
- May-2015
- Publisher
- AMER CHEMICAL SOC
- Keywords
- Adipose-derived stem cells; copper-64; hexadecyl benzoate; radiotracer; PET
- Citation
- ACS MEDICINAL CHEMISTRY LETTERS, v.6, no.5, pp.528 - 530
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACS MEDICINAL CHEMISTRY LETTERS
- Volume
- 6
- Number
- 5
- Start Page
- 528
- End Page
- 530
- ISSN
- 1948-5875
- Abstract
- The purpose of this study was to evaluate Cu-64-labeled hexadecyl-1,4,7,10-tetraazacyclododecane-tetraacetic acid-benzoate (Cu-64-DOTA-HB) (1) as positron emission tomography (PET) radiotracer for stem cell imaging. Hexadecyl-DOTA-benzoate (DOTA-HB) (2) was efficiently labeled with Cu-64 (>99%), and cell labeling efficiency with adipose-derived stem cells (ADSCs) was over 50%. Labeling with 1 did not compromise cell viability. In the PET imaging, intramuscularly transplanted 1-labeled ADSCs were monitored for 18 h in normal rat heart. These results indicate that 1 can be utilized as a promising radiotracer for monitoring of transplanted stem cells.
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