Association of ARRB1 polymorphisms with the risk of major depressive disorder and with treatment response to mirtazapine
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chang, Hun Soo | - |
dc.contributor.author | Won, Eun Soo | - |
dc.contributor.author | Lee, Hwa-Young | - |
dc.contributor.author | Ham, Byung-Joo | - |
dc.contributor.author | Kim, Yong-Gu | - |
dc.contributor.author | Lee, Min-Soo | - |
dc.date.accessioned | 2021-09-04T16:27:24Z | - |
dc.date.available | 2021-09-04T16:27:24Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 0269-8811 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93687 | - |
dc.description.abstract | -Arrestin 1 is known to be involved in the pathophysiology of major depressive disorder (MDD) and in the underlying mechanism of action of antidepressant therapies. After we screened 39 ARRB1 polymorphisms, we investigated the associations of seven ARRB1 single-nucleotide polymorphisms (SNPs) with the risk of MDD in 270 patients with MDD and 204 normal subjects, and with mirtazapine treatment response in patients with MDD. The genotype distributions of -132C>T and IVS1+85T>C showed significant deviations from Hardy-Weinberg equilibrium in patients with MDD but not in normal subjects. After four and 12 weeks of mirtazapine treatment, the proportion of haplotype 1 (ht1) carriers was significantly higher in remitters than in non-remitters after corrections for multiple comparisons (corrected p=0.006 and 0.014 at four and 12 weeks, respectively). After eight and 12 weeks of treatment, scores on the 21-item Hamilton Depression Rating Scale (HAMD21) were significantly lower in patients with MDD with ARRB1 ht1 than in those without ht1. Similarly, after 8 and 12 weeks of treatment, the percent reduction in HAMD21 scores was significantly higher in patients with MDD with ARRB1 ht1 than in those without ht1. The ARRB1 polymorphisms represent promising genetic markers for the prediction of treatment responses to mirtazapine. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.subject | PROTEIN-COUPLED RECEPTORS | - |
dc.subject | MONONUCLEAR LEUKOCYTES | - |
dc.subject | BETA-ARRESTINS | - |
dc.subject | ANTIDEPRESSANTS | - |
dc.subject | BETA-ARRESTIN-1 | - |
dc.subject | EXPRESSION | - |
dc.subject | SIGNALS | - |
dc.subject | CELLS | - |
dc.subject | CREB | - |
dc.title | Association of ARRB1 polymorphisms with the risk of major depressive disorder and with treatment response to mirtazapine | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ham, Byung-Joo | - |
dc.contributor.affiliatedAuthor | Lee, Min-Soo | - |
dc.identifier.doi | 10.1177/0269881114554273 | - |
dc.identifier.scopusid | 2-s2.0-84930674741 | - |
dc.identifier.wosid | 000354903600011 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PSYCHOPHARMACOLOGY, v.29, no.5, pp.615 - 622 | - |
dc.relation.isPartOf | JOURNAL OF PSYCHOPHARMACOLOGY | - |
dc.citation.title | JOURNAL OF PSYCHOPHARMACOLOGY | - |
dc.citation.volume | 29 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 615 | - |
dc.citation.endPage | 622 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | PROTEIN-COUPLED RECEPTORS | - |
dc.subject.keywordPlus | MONONUCLEAR LEUKOCYTES | - |
dc.subject.keywordPlus | BETA-ARRESTINS | - |
dc.subject.keywordPlus | ANTIDEPRESSANTS | - |
dc.subject.keywordPlus | BETA-ARRESTIN-1 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SIGNALS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CREB | - |
dc.subject.keywordAuthor | -Arrestin 1 | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | major depressive disorder | - |
dc.subject.keywordAuthor | mirtazapine | - |
dc.subject.keywordAuthor | treatment response | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.