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Association of ARRB1 polymorphisms with the risk of major depressive disorder and with treatment response to mirtazapine

Authors
Chang, Hun SooWon, Eun SooLee, Hwa-YoungHam, Byung-JooKim, Yong-GuLee, Min-Soo
Issue Date
5월-2015
Publisher
SAGE PUBLICATIONS LTD
Keywords
-Arrestin 1; polymorphism; major depressive disorder; mirtazapine; treatment response
Citation
JOURNAL OF PSYCHOPHARMACOLOGY, v.29, no.5, pp.615 - 622
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF PSYCHOPHARMACOLOGY
Volume
29
Number
5
Start Page
615
End Page
622
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/93687
DOI
10.1177/0269881114554273
ISSN
0269-8811
Abstract
-Arrestin 1 is known to be involved in the pathophysiology of major depressive disorder (MDD) and in the underlying mechanism of action of antidepressant therapies. After we screened 39 ARRB1 polymorphisms, we investigated the associations of seven ARRB1 single-nucleotide polymorphisms (SNPs) with the risk of MDD in 270 patients with MDD and 204 normal subjects, and with mirtazapine treatment response in patients with MDD. The genotype distributions of -132C>T and IVS1+85T>C showed significant deviations from Hardy-Weinberg equilibrium in patients with MDD but not in normal subjects. After four and 12 weeks of mirtazapine treatment, the proportion of haplotype 1 (ht1) carriers was significantly higher in remitters than in non-remitters after corrections for multiple comparisons (corrected p=0.006 and 0.014 at four and 12 weeks, respectively). After eight and 12 weeks of treatment, scores on the 21-item Hamilton Depression Rating Scale (HAMD21) were significantly lower in patients with MDD with ARRB1 ht1 than in those without ht1. Similarly, after 8 and 12 weeks of treatment, the percent reduction in HAMD21 scores was significantly higher in patients with MDD with ARRB1 ht1 than in those without ht1. The ARRB1 polymorphisms represent promising genetic markers for the prediction of treatment responses to mirtazapine.
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