Romo1 and the NF-kappa B pathway are involved in oxidative stress-induced tumor cell invasion
DC Field | Value | Language |
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dc.contributor.author | Lee, Sora | - |
dc.contributor.author | Park, Yoon Hee | - |
dc.contributor.author | Chung, Jin Sil | - |
dc.contributor.author | Yoo, Young Do | - |
dc.date.accessioned | 2021-09-04T16:49:00Z | - |
dc.date.available | 2021-09-04T16:49:00Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 1019-6439 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93746 | - |
dc.description.abstract | Reactive oxygen species (ROS) are important contributors to tumor cell invasion. ROS enhanced by reactive oxygen species modulator 1 (Romol) expression has been reported to increase invasive potential and constitutive activation of nuclear factor-kappa B (NF-kappa B) in hepatocellular carcinoma (HCC). Therefore, we investigated whether constitutive NF-kappa B activation due to Romol expression is associated with breast cancer tumor cell invasion. In this study, we show that oxidative stress-induced invasion is mediated by Romol expression. The Romol-induced increase of invasive activity was blocked by an inhibitor of kappa B kinase (IKK). These tesults demonstrate that tumor cell invasion in response to oxidative stress is associated with Romol expression and the NF-kappa B signaling pathway. Romol is therefore a promising therapeutic target for diseases characterized by NF-kappa B deregulation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.subject | OXYGEN SPECIES PRODUCTION | - |
dc.subject | TRANSCRIPTION FACTOR | - |
dc.subject | HYDROGEN-PEROXIDE | - |
dc.subject | EPITHELIAL-CELLS | - |
dc.subject | ROS PRODUCTION | - |
dc.subject | ACTIVATION | - |
dc.subject | CANCER | - |
dc.subject | EXPRESSION | - |
dc.subject | CARCINOMA | - |
dc.subject | IKK | - |
dc.title | Romo1 and the NF-kappa B pathway are involved in oxidative stress-induced tumor cell invasion | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Young Do | - |
dc.identifier.doi | 10.3892/ijo.2015.2889 | - |
dc.identifier.scopusid | 2-s2.0-84925436766 | - |
dc.identifier.wosid | 000353180800018 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF ONCOLOGY, v.46, no.5, pp.2021 - 2028 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF ONCOLOGY | - |
dc.citation.title | INTERNATIONAL JOURNAL OF ONCOLOGY | - |
dc.citation.volume | 46 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 2021 | - |
dc.citation.endPage | 2028 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | OXYGEN SPECIES PRODUCTION | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | ROS PRODUCTION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | IKK | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
dc.subject.keywordAuthor | nuclear factor-kappa B | - |
dc.subject.keywordAuthor | tumor invasion | - |
dc.subject.keywordAuthor | Romo1 | - |
dc.subject.keywordAuthor | oxidative stress | - |
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