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Romo1 and the NF-kappa B pathway are involved in oxidative stress-induced tumor cell invasion

Authors
Lee, SoraPark, Yoon HeeChung, Jin SilYoo, Young Do
Issue Date
5월-2015
Publisher
SPANDIDOS PUBL LTD
Keywords
reactive oxygen species; nuclear factor-kappa B; tumor invasion; Romo1; oxidative stress
Citation
INTERNATIONAL JOURNAL OF ONCOLOGY, v.46, no.5, pp.2021 - 2028
Indexed
SCIE
SCOPUS
Journal Title
INTERNATIONAL JOURNAL OF ONCOLOGY
Volume
46
Number
5
Start Page
2021
End Page
2028
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/93746
DOI
10.3892/ijo.2015.2889
ISSN
1019-6439
Abstract
Reactive oxygen species (ROS) are important contributors to tumor cell invasion. ROS enhanced by reactive oxygen species modulator 1 (Romol) expression has been reported to increase invasive potential and constitutive activation of nuclear factor-kappa B (NF-kappa B) in hepatocellular carcinoma (HCC). Therefore, we investigated whether constitutive NF-kappa B activation due to Romol expression is associated with breast cancer tumor cell invasion. In this study, we show that oxidative stress-induced invasion is mediated by Romol expression. The Romol-induced increase of invasive activity was blocked by an inhibitor of kappa B kinase (IKK). These tesults demonstrate that tumor cell invasion in response to oxidative stress is associated with Romol expression and the NF-kappa B signaling pathway. Romol is therefore a promising therapeutic target for diseases characterized by NF-kappa B deregulation.
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