Poikiloderma Vasculare Atrophicans Showing Features of Ashy Dermatosis in the Beginning
- Authors
- Jeon, Jiehyun; Kim, Joo Ha; Ahn, Jae Woo; Song, Hae Jun
- Issue Date
- 4월-2015
- Publisher
- KOREAN DERMATOLOGICAL ASSOC
- Keywords
- CD4; CD8; CD4-CD8 ratio; Mycosis fungoides; Poikiloderma; T-lymphocytes
- Citation
- ANNALS OF DERMATOLOGY, v.27, no.2, pp.197 - 200
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ANNALS OF DERMATOLOGY
- Volume
- 27
- Number
- 2
- Start Page
- 197
- End Page
- 200
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/93909
- DOI
- 10.5021/ad.2015.27.2.197
- ISSN
- 1013-9087
- Abstract
- Poikiloderma vasculare atrophicans (PVA) is a rare poikilodermatous variant of early-stage mycosis fungoides characterized by generalized poikiloderma, atrophy, mottled dys-pigmentation, and telangiectasia. In 2001, a 14-year-old male presented with asymptomatic brownish-gray polymorphic macules throughout the body with flexural accentuation. A skin biopsy showed increased melanophages with focal hydropic changes. Ashy dermatosis was considered a possible diagnosis. In 2005, the lesions began to show darkening and lichenification in the lower part of the trunk. In 2011, his skin showed definite poikilodermatous changes, and a biopsy showed band-like inflammatory infiltrations of atypical lymphocytes, epidermal atrophy, and epidermotropism of predominantly CD4(-)CD8(+) atypical T cells. In addition, results of T-cell receptor gene rearrangement analysis were positive. Based on the aforementioned findings, he was diagnosed with PVA. If a patient shows long-standing and progressive hyperpigmentary skin changes, periodic follow-up and repeated skin biopsies are recommended to determine the underlying condition.
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