MyD88-BLT2-dependent cascade contributes to LPS-induced interleukin-6 production in mouse macrophage
DC Field | Value | Language |
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dc.contributor.author | Lee, A-Jin | - |
dc.contributor.author | Cho, Kyung-Jin | - |
dc.contributor.author | Kim, Jae-Hong | - |
dc.date.accessioned | 2021-09-04T17:35:13Z | - |
dc.date.available | 2021-09-04T17:35:13Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-04 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93917 | - |
dc.description.abstract | Endotoxic responses to bacterial lipopolysaccharide (LPS) are triggered by Toll-like receptor 4 (TLR4) and involve the production of inflammatory mediators, including interleukin-6 (IL-6), by macrophages. The detailed mechanism of IL-6 production by macrophages in response to LPS has remained unclear, however. We now show that LPS induces IL-6 synthesis in mouse peritoneal macrophages via the leukotriene B4 receptor BLT2. Our results suggest that TLR4-MyD88 signaling functions upstream of BLT2 and that the generation of reactive oxygen species (ROS) by NADPH oxidase 1 (Nox1) and consequent activation of the transcription factor nuclear factor (NF)-kappa B function downstream of BLT2 in this response. These results suggest that a TLR4-MyD88-BLT2-Nox1-ROS-NF-kappa B pathway contributes to the synthesis of IL-6 in LPS-stimulated mouse macrophages. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | KAPPA-B ACTIVATION | - |
dc.subject | LEUKOTRIENE B-4 | - |
dc.subject | LIPOPOLYSACCHARIDE | - |
dc.subject | ENDOTOXIN | - |
dc.subject | PATHWAY | - |
dc.subject | MYD88 | - |
dc.subject | INFLAMMATION | - |
dc.subject | CELLS | - |
dc.subject | ANTAGONIST | - |
dc.subject | ACID | - |
dc.title | MyD88-BLT2-dependent cascade contributes to LPS-induced interleukin-6 production in mouse macrophage | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jae-Hong | - |
dc.identifier.doi | 10.1038/emm.2015.8 | - |
dc.identifier.scopusid | 2-s2.0-84965183971 | - |
dc.identifier.wosid | 000358593800002 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.47 | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.volume | 47 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | KAPPA-B ACTIVATION | - |
dc.subject.keywordPlus | LEUKOTRIENE B-4 | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | ENDOTOXIN | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | MYD88 | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ANTAGONIST | - |
dc.subject.keywordPlus | ACID | - |
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