MyD88-BLT2-dependent cascade contributes to LPS-induced interleukin-6 production in mouse macrophage
- Authors
- Lee, A-Jin; Cho, Kyung-Jin; Kim, Jae-Hong
- Issue Date
- 4월-2015
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- EXPERIMENTAL AND MOLECULAR MEDICINE, v.47
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- EXPERIMENTAL AND MOLECULAR MEDICINE
- Volume
- 47
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/93917
- DOI
- 10.1038/emm.2015.8
- ISSN
- 1226-3613
- Abstract
- Endotoxic responses to bacterial lipopolysaccharide (LPS) are triggered by Toll-like receptor 4 (TLR4) and involve the production of inflammatory mediators, including interleukin-6 (IL-6), by macrophages. The detailed mechanism of IL-6 production by macrophages in response to LPS has remained unclear, however. We now show that LPS induces IL-6 synthesis in mouse peritoneal macrophages via the leukotriene B4 receptor BLT2. Our results suggest that TLR4-MyD88 signaling functions upstream of BLT2 and that the generation of reactive oxygen species (ROS) by NADPH oxidase 1 (Nox1) and consequent activation of the transcription factor nuclear factor (NF)-kappa B function downstream of BLT2 in this response. These results suggest that a TLR4-MyD88-BLT2-Nox1-ROS-NF-kappa B pathway contributes to the synthesis of IL-6 in LPS-stimulated mouse macrophages.
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Collections - College of Life Sciences and Biotechnology > Division of Life Sciences > 1. Journal Articles
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