6-Gingerol reduces Pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition
DC Field | Value | Language |
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dc.contributor.author | Kim, Han-Shin | - |
dc.contributor.author | Lee, Sang-Hoon | - |
dc.contributor.author | Byun, Youngjoo | - |
dc.contributor.author | Park, Hee-Deung | - |
dc.date.accessioned | 2021-09-04T18:24:52Z | - |
dc.date.available | 2021-09-04T18:24:52Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2015-03-02 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/94160 | - |
dc.description.abstract | Pseudomonas aeruginosa is a well-known pathogenic bacterium that forms biofilms and produces virulence factors via quorum sensing (QS). Interfering with normal QS interactions between signal molecules and their cognate receptors is a developing strategy for attenuating its virulence. Here we tested the hypothesis that 6-gingerol, a pungent oil of fresh ginger, reduces biofilm formation and virulence by antagonistically binding to P. aeruginosa QS receptors. In silico studies demonstrated molecular binding occurs between 6-gingerol and the QS receptor LasR through hydrogen bonding and hydrophobic interactions. Experimentally 6-gingerol reduced biofilm formation, several virulence factors (e.g., exoprotease, rhamnolipid, and pyocyanin), and mice mortality. Further transcriptome analyses demonstrated that 6-gingerol successfully repressed QS-induced genes, specifically those related to the production of virulence factors. These results strongly support our hypothesis and offer insight into the molecular mechanism that caused QS gene repression. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | BIOLOGICAL EVALUATION | - |
dc.subject | CELL COMMUNICATION | - |
dc.subject | GROWTH-PHASE | - |
dc.subject | GINGER | - |
dc.subject | IDENTIFICATION | - |
dc.subject | PATHOGENESIS | - |
dc.subject | ANTIBIOTICS | - |
dc.subject | AUTOINDUCER | - |
dc.subject | MODULATORS | - |
dc.subject | INFECTION | - |
dc.title | 6-Gingerol reduces Pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sang-Hoon | - |
dc.contributor.affiliatedAuthor | Byun, Youngjoo | - |
dc.contributor.affiliatedAuthor | Park, Hee-Deung | - |
dc.identifier.doi | 10.1038/srep08656 | - |
dc.identifier.scopusid | 2-s2.0-84923882008 | - |
dc.identifier.wosid | 000350300300001 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.5 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 5 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | BIOLOGICAL EVALUATION | - |
dc.subject.keywordPlus | CELL COMMUNICATION | - |
dc.subject.keywordPlus | GROWTH-PHASE | - |
dc.subject.keywordPlus | GINGER | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | ANTIBIOTICS | - |
dc.subject.keywordPlus | AUTOINDUCER | - |
dc.subject.keywordPlus | MODULATORS | - |
dc.subject.keywordPlus | INFECTION | - |
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