Associations between the angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to sarcoidosis: A meta-analysis
- Authors
- Song, Gwan Gyu; Kim, Jae-Hoon; Lee, Young Ho
- Issue Date
- 3월-2015
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- Angiotensin-converting enzyme; meta-analysis; polymorphism; sarcoidosis
- Citation
- JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, v.16, no.1, pp.219 - 226
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
- Volume
- 16
- Number
- 1
- Start Page
- 219
- End Page
- 226
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/94175
- DOI
- 10.1177/1470320313489059
- ISSN
- 1470-3203
- Abstract
- Introduction: The purpose of this study was to examine whether the insertion (I) or deletion (D) of angiotensin-converting enzyme (ACE) polymorphism confers susceptibility to sarcoidosis. Methods: A meta-analysis on the associations between the ACE I/D polymorphism and sarcoidosis was conducted. Results: Seventeen comparison studies consisting of 1556 cases and 2381 controls were available for the meta-analysis. Meta-analysis revealed a significant association between the D allele and sarcoidosis (OR 1.206, 95% CI 1.049-1.386, p = 0.009). An ethnicity-specific meta-analysis of the DD+ID genotype showed an association with sarcoidosis in East Asians (OR 1.342, 95% CI 1.041-1.729, p = 0.023). An association was found between the DD genotype of the ACE I/D polymorphism and sarcoidosis (OR 1.251, 95% CI 1.070-1.463, p = 0.005). Furthermore, stratification by ethnicity indicated an association between the DD genotype and sarcoidosis in Europeans (OR = 1.215, 95% CI = 1.010-1.462, p = 0.039). Conclusions: Our meta-analysis demonstrates that the ACE I/D polymorphism is associated with susceptibility to sarcoidosis in European and East Asian populations.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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