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Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata
- Authors
- Nguyen Tuan Hiep; Kwon, Jaeyoung; Kim, Dong-Woo; Hwang, Bang Yeon; Lee, Hak-Ju; Mar, Woongchon; Lee, Dongho
- Issue Date
- 3월-2015
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Cudrania tricuspidata; Moraceae; Isoflavones; Neuroprotection; Parkinson' s disease; 6-OHDA; Human neuroblastoma SH-SY5Y
- Citation
- PHYTOCHEMISTRY, v.111, pp.141 - 148
- Indexed
- SCIE
SCOPUS
- Journal Title
- PHYTOCHEMISTRY
- Volume
- 111
- Start Page
- 141
- End Page
- 148
- ISSN
- 0031-9422
- Abstract
- Ten isoflavones, cudraisoflavones B-K (1-10), together with 27 known isoflavones, were isolated from the EtOAc soluble extract of fruits of Cudrania tricuspidata. The structures of compounds 1-10 were elucidated on the basis of MS and NMR spectroscopic data, including 2D NMR experiments. Compounds 7-9 and three known (11-13) compounds showed neuroprotective activity against 6-hydroxydopamine induced cell death in human neuroblastoma SH-SY5Y cells, with EC50 values of 0.5-9.2 mu M. (C) 2014 Elsevier Ltd. All rights reserved.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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