Dehydrozingerone exerts beneficial metabolic effects in high-fat diet-induced obese mice via AMPK activation in skeletal muscle
DC Field | Value | Language |
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dc.contributor.author | Kim, Su Jin | - |
dc.contributor.author | Kim, Hong Min | - |
dc.contributor.author | Lee, Eun Soo | - |
dc.contributor.author | Kim, Nami | - |
dc.contributor.author | Lee, Jung Ok | - |
dc.contributor.author | Lee, Hye Jeong | - |
dc.contributor.author | Park, Na Yeon | - |
dc.contributor.author | Jo, Joo Yeon | - |
dc.contributor.author | Ham, Bo Young | - |
dc.contributor.author | Han, Si Hyun | - |
dc.contributor.author | Park, Sun Hwa | - |
dc.contributor.author | Chung, Choon Hee | - |
dc.contributor.author | Kim, Hyeon Soo | - |
dc.date.accessioned | 2021-09-04T18:36:21Z | - |
dc.date.available | 2021-09-04T18:36:21Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 1582-1838 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/94233 | - |
dc.description.abstract | Dehydrozingerone (DHZ) exerts beneficial effects on human health; however, its mechanism of action remains unclear. Here, we found that DHZ suppressed high-fat diet-induced weight gain, lipid accumulation and hyperglycaemia in C57BL/6 mice and increased AMP-activated protein kinase (AMPK) phosphorylation and stimulated glucose uptake in C2C12 skeletal muscle cells. DHZ activated p38 mitogen-activated protein kinase (MAPK) signalling in an AMPK-dependent manner. Inhibiting AMPK or p38 MAPK blocked DHZ-induced glucose uptake. DHZ increased GLUT4 (major transporter for glucose uptake) expression in skeletal muscle. Glucose clearance and insulin-induced glucose uptake increased in DHZ-fed animals, suggesting that DHZ increases systemic insulin sensitivity in vivo. Thus, the beneficial health effects of DHZ could possibly be explained by its ability to activate the AMPK pathway in skeletal muscle. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | PROTEIN-KINASE | - |
dc.subject | GLUCOSE-UPTAKE | - |
dc.subject | MAP-KINASE | - |
dc.subject | CURCUMIN | - |
dc.subject | CELLS | - |
dc.subject | RAT | - |
dc.subject | STIMULATION | - |
dc.subject | SESQUITERPENOIDS | - |
dc.subject | ANTIOXIDANT | - |
dc.subject | TRANSPORT | - |
dc.title | Dehydrozingerone exerts beneficial metabolic effects in high-fat diet-induced obese mice via AMPK activation in skeletal muscle | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Sun Hwa | - |
dc.contributor.affiliatedAuthor | Kim, Hyeon Soo | - |
dc.identifier.doi | 10.1111/jcmm.12455 | - |
dc.identifier.scopusid | 2-s2.0-84923506544 | - |
dc.identifier.wosid | 000350348500010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v.19, no.3, pp.620 - 629 | - |
dc.relation.isPartOf | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | - |
dc.citation.title | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | - |
dc.citation.volume | 19 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 620 | - |
dc.citation.endPage | 629 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | GLUCOSE-UPTAKE | - |
dc.subject.keywordPlus | MAP-KINASE | - |
dc.subject.keywordPlus | CURCUMIN | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | STIMULATION | - |
dc.subject.keywordPlus | SESQUITERPENOIDS | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | TRANSPORT | - |
dc.subject.keywordAuthor | AMPK | - |
dc.subject.keywordAuthor | curcumin analogue | - |
dc.subject.keywordAuthor | dehydrozingerone | - |
dc.subject.keywordAuthor | glucose uptake | - |
dc.subject.keywordAuthor | metabolism | - |
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