Dehydrozingerone exerts beneficial metabolic effects in high-fat diet-induced obese mice via AMPK activation in skeletal muscle
- Authors
- Kim, Su Jin; Kim, Hong Min; Lee, Eun Soo; Kim, Nami; Lee, Jung Ok; Lee, Hye Jeong; Park, Na Yeon; Jo, Joo Yeon; Ham, Bo Young; Han, Si Hyun; Park, Sun Hwa; Chung, Choon Hee; Kim, Hyeon Soo
- Issue Date
- 3월-2015
- Publisher
- WILEY
- Keywords
- AMPK; curcumin analogue; dehydrozingerone; glucose uptake; metabolism
- Citation
- JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v.19, no.3, pp.620 - 629
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Volume
- 19
- Number
- 3
- Start Page
- 620
- End Page
- 629
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/94233
- DOI
- 10.1111/jcmm.12455
- ISSN
- 1582-1838
- Abstract
- Dehydrozingerone (DHZ) exerts beneficial effects on human health; however, its mechanism of action remains unclear. Here, we found that DHZ suppressed high-fat diet-induced weight gain, lipid accumulation and hyperglycaemia in C57BL/6 mice and increased AMP-activated protein kinase (AMPK) phosphorylation and stimulated glucose uptake in C2C12 skeletal muscle cells. DHZ activated p38 mitogen-activated protein kinase (MAPK) signalling in an AMPK-dependent manner. Inhibiting AMPK or p38 MAPK blocked DHZ-induced glucose uptake. DHZ increased GLUT4 (major transporter for glucose uptake) expression in skeletal muscle. Glucose clearance and insulin-induced glucose uptake increased in DHZ-fed animals, suggesting that DHZ increases systemic insulin sensitivity in vivo. Thus, the beneficial health effects of DHZ could possibly be explained by its ability to activate the AMPK pathway in skeletal muscle.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.