The miR-146a polymorphism and susceptibility to systemic lupus erythematosus and rheumatoid arthritis A meta-analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Y. H. | - |
dc.contributor.author | Bae, S. -C. | - |
dc.date.accessioned | 2021-09-04T18:36:33Z | - |
dc.date.available | 2021-09-04T18:36:33Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 0340-1855 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/94234 | - |
dc.description.abstract | The aim of this study was to explore whether the miR-146a polymorphism (rs2910164) confers susceptibility to systemic lupus erythematous (SLE) and rheumatoid arthritis (RA). A meta-analysis was conducted on the association of the miR-146a polymorphism with SLE and RA. Five studies with 2013 patients and 2555 controls were included in the meta-analysis. Meta-analysis revealed no association between SLE and the miR-146a G allele (odds ratio, OR = 1.007, 95 % confidence interval, CI = 0.910-1.114, p = 0.888). Additionally, no associations were found between the miR-146a polymorphism and SLE using recessive or dominant models, or homozygote contrast. Meta-analysis using allele contrast, recessive and dominant models, as well as homozygote contrast failed to reveal an association between the miR-146a polymorphism and RA (OR for G allele = 1.114, 95 % CI = 0.892-1.391, p = 0.342). This meta-analysis demonstrates that the miR-146a polymorphism is not associated with susceptibility to SLE and RA. However, considering the small number of studies, further studies are needed to confirm this result. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.subject | GENOME SCAN METAANALYSIS | - |
dc.subject | GENE | - |
dc.subject | EXPRESSION | - |
dc.subject | CARCINOMA | - |
dc.title | The miR-146a polymorphism and susceptibility to systemic lupus erythematosus and rheumatoid arthritis A meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Y. H. | - |
dc.identifier.doi | 10.1007/s00393-014-1509-6 | - |
dc.identifier.scopusid | 2-s2.0-84939962499 | - |
dc.identifier.wosid | 000351708900017 | - |
dc.identifier.bibliographicCitation | ZEITSCHRIFT FUR RHEUMATOLOGIE, v.74, no.2, pp.153 - 156 | - |
dc.relation.isPartOf | ZEITSCHRIFT FUR RHEUMATOLOGIE | - |
dc.citation.title | ZEITSCHRIFT FUR RHEUMATOLOGIE | - |
dc.citation.volume | 74 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 153 | - |
dc.citation.endPage | 156 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | GENOME SCAN METAANALYSIS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordAuthor | MicroRNAs | - |
dc.subject.keywordAuthor | Autoimmune disease | - |
dc.subject.keywordAuthor | Inflammatory disease | - |
dc.subject.keywordAuthor | Ethnicity | - |
dc.subject.keywordAuthor | Polymorphism, single nucleotide | - |
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