The miR-146a polymorphism and susceptibility to systemic lupus erythematosus and rheumatoid arthritis A meta-analysis
- Authors
- Lee, Y. H.; Bae, S. -C.
- Issue Date
- 3월-2015
- Publisher
- SPRINGER HEIDELBERG
- Keywords
- MicroRNAs; Autoimmune disease; Inflammatory disease; Ethnicity; Polymorphism, single nucleotide
- Citation
- ZEITSCHRIFT FUR RHEUMATOLOGIE, v.74, no.2, pp.153 - 156
- Indexed
- SCIE
SCOPUS
- Journal Title
- ZEITSCHRIFT FUR RHEUMATOLOGIE
- Volume
- 74
- Number
- 2
- Start Page
- 153
- End Page
- 156
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/94234
- DOI
- 10.1007/s00393-014-1509-6
- ISSN
- 0340-1855
- Abstract
- The aim of this study was to explore whether the miR-146a polymorphism (rs2910164) confers susceptibility to systemic lupus erythematous (SLE) and rheumatoid arthritis (RA). A meta-analysis was conducted on the association of the miR-146a polymorphism with SLE and RA. Five studies with 2013 patients and 2555 controls were included in the meta-analysis. Meta-analysis revealed no association between SLE and the miR-146a G allele (odds ratio, OR = 1.007, 95 % confidence interval, CI = 0.910-1.114, p = 0.888). Additionally, no associations were found between the miR-146a polymorphism and SLE using recessive or dominant models, or homozygote contrast. Meta-analysis using allele contrast, recessive and dominant models, as well as homozygote contrast failed to reveal an association between the miR-146a polymorphism and RA (OR for G allele = 1.114, 95 % CI = 0.892-1.391, p = 0.342). This meta-analysis demonstrates that the miR-146a polymorphism is not associated with susceptibility to SLE and RA. However, considering the small number of studies, further studies are needed to confirm this result.
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