Associations between the insertion/deletion polymorphism of the angiotensin-converting enzyme and susceptibility to aortic aneurysms: A meta-analysis
- Authors
- Song, Gwan Gyu; Kim, Jae-Hoon; Lee, Young Ho
- Issue Date
- 3월-2015
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- Angiotensin-converting enzyme; meta-analysis; polymorphism; abdominal aortic aneurysm
- Citation
- JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, v.16, no.1, pp.211 - 218
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
- Volume
- 16
- Number
- 1
- Start Page
- 211
- End Page
- 218
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/94244
- DOI
- 10.1177/1470320313485897
- ISSN
- 1470-3203
- Abstract
- Introduction: The purpose of this study is to examine whether the insertion (I) and deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) confers susceptibility to aortic aneurysms (AAs). Materials and methods: A meta-analysis was conducted on the associations between the ACE I/D polymorphism and all AAs and abdominal aortic aneurysms (AAAs). Results: Ten studies consisting of 2784 cases and 2682 controls were available for the meta-analysis. Meta-analysis showed a significant association between the D allele and all types of AA (OR 1.378, 95% CI 1.103-1.723, p = 0.005) and AAA (OR 1.274, 95% CI 1.004-1.617, p = 0.046). Meta-analysis of both the DD genotype and the DD vs. II genotype showed an association with AAAs. Stratification by ethnicity indicated an association between the D allele of the ACE I/D polymorphism and AAAs in Europeans (OR = 1.338, 95% CI = 1.026-1.745, p = 0.031), but not in Asians (OR = 0.927, 95% CI = 0.660-1.303, p = 0.663). Furthermore, analysis using the recessive model, dominant model, and homozygote contrast all showed the same pattern for the D allele. Conclusions: Our meta-analysis demonstrates that the ACE I/D polymorphism is associated with susceptibility to AAAs in European populations.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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