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Inhibitory constituents of Sophora tonkinensis on nitric oxide production in RAW 264.7 macrophages
- Authors
- Lee, Jin Woo; Lee, Ji Hoon; Lee, Chul; Jin, Qinghao; Lee, Dongho; Kim, Youngsoo; Hong, Jin Tae; Lee, Mi Kyeong; Hwang, Bang Yeon
- Issue Date
- 15-Feb-2015
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Sophora tonkinensis; Leguminosae; Pterocarpan; Nitric oxide production inhibitor
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.25, no.4, pp.960 - 962
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 25
- Number
- 4
- Start Page
- 960
- End Page
- 962
- ISSN
- 0960-894X
- Abstract
- Bioactivity-guided fractionation of the MeOH extract from the roots of Sophora tonkinensis resulted in the isolation of a new pterocarpan glycoside (1) together with nine known compounds, maackiain (2), sophoranone (3), sophoranochromene (4), pinoresinol (5), syringaresinol (6), medioresinol (7), 4',7-dihydroxyflavone (8), calycosin (9), and genistein (10). The structure of the new compound was determined on the basis of spectroscopic analysis including NMR and CD data in combination with acid hydrolysis. Compounds 1-4 exhibited the inhibitory effects on LPS-induced nitric oxide production with IC50 values ranging from 13.6 to 33.0 mu M in RAW 264.7 macrophages. (C) 2014 Elsevier Ltd. All rights reserved.
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Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology