Human amniotic membrane-derived stromal cells (hAMSC) interact depending on breast cancer cell type through secreted molecules
DC Field | Value | Language |
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dc.contributor.author | Kim, Sun-Hee | - |
dc.contributor.author | Bang, So Hee | - |
dc.contributor.author | Kang, So Yeong | - |
dc.contributor.author | Park, Ki Dae | - |
dc.contributor.author | Eom, Jun Ho | - |
dc.contributor.author | Oh, Il Ung | - |
dc.contributor.author | Yoo, Si Hyung | - |
dc.contributor.author | Kim, Chan-Wha | - |
dc.contributor.author | Baek, Sun Young | - |
dc.date.accessioned | 2021-09-04T19:46:52Z | - |
dc.date.available | 2021-09-04T19:46:52Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 0040-8166 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/94583 | - |
dc.description.abstract | Human amniotic membrane-derived stromal cells (hAMSC) are candidates for cell-based therapies. We examined the characteristics of hAMSC including the interaction between hAMSC and breast cancer cells, MCF-7, and MDA-MB-231. Human amniotic membrane-derived stromal cells showed typical MSC properties, including fibroblast-like morphology, surface antigen expression, and mesodermal differentiation. To investigate cell-cell interaction via secreted molecules, we cultured breast cancer cells in hAMSC-conditioned medium (hAMSC-CM) and analyzed their proliferation, migration, and secretome profiles. MCF-7 and MDA-MB-231 cells exposed to hAMSC-CM showed increased proliferation and migration. However, in hAMSC-CM, MCF-7 cells proliferated significantly faster than MDA-MB-231 cells. When cultured in hAMSC-CM, MCF-7 cells migrated faster than MDA-MB-231 cells. Two cell types showed different profiles of secreted factors. MCF-7 cells expressed much amounts of IL-8, GRO, and MCP-1 in hAMSC-CM. Human amniotic membrane-derived stromal cells interact with breast cancer cells through secreted molecules. Factors secreted by hAMSCs promote the proliferation and migration of MCF-7 breast cancer cells. For much safe cell-based therapies using hAMSC, it is necessary to study carefully about interaction between hAMSC and cancer cells. (C) 2014 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CHURCHILL LIVINGSTONE | - |
dc.subject | MESENCHYMAL STEM-CELLS | - |
dc.subject | TERM PLACENTA | - |
dc.subject | BONE-MARROW | - |
dc.subject | IN-VITRO | - |
dc.subject | OVEREXPRESSION | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | INVASION | - |
dc.subject | THERAPY | - |
dc.subject | GROWTH | - |
dc.subject | FETAL | - |
dc.title | Human amniotic membrane-derived stromal cells (hAMSC) interact depending on breast cancer cell type through secreted molecules | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chan-Wha | - |
dc.identifier.doi | 10.1016/j.tice.2014.10.003 | - |
dc.identifier.scopusid | 2-s2.0-84923834853 | - |
dc.identifier.wosid | 000349982000002 | - |
dc.identifier.bibliographicCitation | TISSUE & CELL, v.47, no.1, pp.10 - 16 | - |
dc.relation.isPartOf | TISSUE & CELL | - |
dc.citation.title | TISSUE & CELL | - |
dc.citation.volume | 47 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 10 | - |
dc.citation.endPage | 16 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Anatomy & Morphology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Anatomy & Morphology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | TERM PLACENTA | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | FETAL | - |
dc.subject.keywordAuthor | Amniotic membrane | - |
dc.subject.keywordAuthor | MCF-7 | - |
dc.subject.keywordAuthor | MDA-MB-231 | - |
dc.subject.keywordAuthor | Secretion | - |
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