ER alpha regulates chromosome alignment and spindle dynamics during mitosis
- Authors
- Zhang, Xianghua; Park, Hweon; Han, Sung-Sik; Kim, Jung Woo; Jang, Chang-Young
- Issue Date
- 24-Jan-2015
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- ER alpha; Mitotic spindle; Chromosome movement; Spindle dynamics
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.456, no.4, pp.919 - 925
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 456
- Number
- 4
- Start Page
- 919
- End Page
- 925
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/94617
- DOI
- 10.1016/j.bbrc.2014.12.062
- ISSN
- 0006-291X
- Abstract
- Estrogen receptors are activated by the hormone estrogen and they control cell growth by altering gene expression as a transcription factor. So far two estrogen receptors have been found: ER alpha and ER beta. Estrogen receptors are also implicated in the development and progression of breast cancer. Here, we found that ER alpha, localized on the spindle and spindle poles at the metaphase during mitosis. Depletion of ER alpha generated unaligned chromosomes in metaphase cells and lagging chromosomes in anaphase cells in a transcription-independent manner. Furthermore, the levels of beta-tubulin and gamma-tubulin were reduced in ER alpha-depleted cells. Consistent with this, polymerization of microtubules in ER alpha-depleted cells and turnover rate of alpha/beta-tubulin were decreased than in control cells. We suggest that ER alpha regulates chromosome alignment and spindle dynamics by stabilizing microtubules during mitosis. (C) 2014 Elsevier Inc. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Life Sciences and Biotechnology > Division of Life Sciences > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholar.korea.ac.kr/handle/2021.sw.korea/94617)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.