Blood-compatible Bio-inspired Surface of Poly(L-lactide-co-epsilon-caprolactone) Films Prepared Using Poor Co-solvent Casting
- Authors
- Lim, Jin Ik; Kim, Soo Hyun
- Issue Date
- 1월-2015
- Publisher
- POLYMER SOC KOREA
- Keywords
- antithrombotic material; lotus-leaf-like structure; co-solvent system; blood vessel; surface modification
- Citation
- POLYMER-KOREA, v.39, no.1, pp.40 - 45
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- POLYMER-KOREA
- Volume
- 39
- Number
- 1
- Start Page
- 40
- End Page
- 45
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/94793
- DOI
- 10.7317/pk.2015.39.1.40
- ISSN
- 0379-153X
- Abstract
- Simple poor-cosolvent casting was used to surface treat biodegradable elastic poly(L-lactide-co-epsilon-caprolactone) (PLCL; 50:50) copolymer films that presented lotus-leaf-like structures. We evaluated whether the lotus-leaflike-structured PLCL (L-PLCL) films could be used as a biomaterial for artificial vascular grafts. The surface morphology, hydrophobicity, and antithrombotic efficiency of the films were examined while immersed in platelet-rich plasma (PRP) using scanning electron microscopy (SEM) and a contact angle meter. The recovery and crystallinity of the films were measured using a tensile-strength testing machine and an X-ray diffractometer, respectively. The solvent containing acetic acid, as a poor co-solvent, and methylene chloride mixed in a 1:2 ratio produced an optimal PLCL film with a water contact angle of approximately 124 degrees. Furthermore, the surface of the L-PLCL films immersed in PRP showed a lower rate of platelet adhesion (<10%) than that of the surface of an untreated PLCL film immersed in PRP.
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Collections - Graduate School > KU-KIST Graduate School of Converging Science and Technology > 1. Journal Articles
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