Activating Injury-Responsive Genes with Hypoxia Enhances Axon Regeneration through Neuronal HIF-1α
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Y. | - |
dc.contributor.author | Shin, J.E. | - |
dc.contributor.author | Ewan, E.E. | - |
dc.contributor.author | Oh, Y.M. | - |
dc.contributor.author | Pita-Thomas, W. | - |
dc.contributor.author | Cavalli, V. | - |
dc.date.accessioned | 2021-09-04T23:51:47Z | - |
dc.date.available | 2021-09-04T23:51:47Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/95888 | - |
dc.description.abstract | Injured peripheral neurons successfully activate a proregenerative transcriptional program to enable axon regeneration and functional recovery. How transcriptional regulators coordinate the expression of such program remains unclear. Here we show that hypoxia-inducible factor 1α (HIF-1α) controls multiple injury-induced genes in sensory neurons and contribute to the preconditioning lesion effect. Knockdown of HIF-1α in vitro or conditional knock out in vivo impairs sensory axon regeneration. The HIF-1α target gene Vascular Endothelial Growth Factor A (VEGFA) is expressed in injured neurons and contributes to stimulate axon regeneration. Induction of HIF-1α using hypoxia enhances axon regeneration in vitro and in vivo in sensory neurons. Hypoxia also stimulates motor neuron regeneration and accelerates neuromuscular junction re-innervation. This study demonstrates that HIF-1α represents a critical transcriptional regulator in regenerating neurons and suggests hypoxia as a tool to stimulate axon regeneration. © 2015 Elsevier Inc. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | Cell Press | - |
dc.subject | hypoxia inducible factor 1alpha | - |
dc.subject | vasculotropin A | - |
dc.subject | Hif1a protein, mouse | - |
dc.subject | hypoxia inducible factor 1alpha | - |
dc.subject | vascular endothelial growth factor A, mouse | - |
dc.subject | vasculotropin A | - |
dc.subject | animal cell | - |
dc.subject | animal experiment | - |
dc.subject | animal tissue | - |
dc.subject | Article | - |
dc.subject | cell hypoxia | - |
dc.subject | controlled study | - |
dc.subject | embryo | - |
dc.subject | female | - |
dc.subject | gene silencing | - |
dc.subject | in vitro study | - |
dc.subject | in vivo study | - |
dc.subject | male | - |
dc.subject | motoneuron | - |
dc.subject | mouse | - |
dc.subject | muscle reinnervation | - |
dc.subject | nerve cell lesion | - |
dc.subject | nerve fiber regeneration | - |
dc.subject | neuromuscular synapse | - |
dc.subject | nonhuman | - |
dc.subject | priority journal | - |
dc.subject | protein expression | - |
dc.subject | sensory nerve cell | - |
dc.subject | transcription regulation | - |
dc.subject | upregulation | - |
dc.subject | animal | - |
dc.subject | axon | - |
dc.subject | cell culture | - |
dc.subject | cytology | - |
dc.subject | gene expression regulation | - |
dc.subject | genetics | - |
dc.subject | hypoxia | - |
dc.subject | injuries | - |
dc.subject | metabolism | - |
dc.subject | nerve regeneration | - |
dc.subject | neuromuscular junction | - |
dc.subject | peripheral nerve injury | - |
dc.subject | sciatic nerve | - |
dc.subject | sensory nerve cell | - |
dc.subject | spinal ganglion | - |
dc.subject | Animals | - |
dc.subject | Axons | - |
dc.subject | Cells, Cultured | - |
dc.subject | Ganglia, Spinal | - |
dc.subject | Gene Expression Regulation | - |
dc.subject | Gene Knockdown Techniques | - |
dc.subject | Hypoxia | - |
dc.subject | Hypoxia-Inducible Factor 1, alpha Subunit | - |
dc.subject | In Vitro Techniques | - |
dc.subject | Mice | - |
dc.subject | Motor Neurons | - |
dc.subject | Nerve Regeneration | - |
dc.subject | Neuromuscular Junction | - |
dc.subject | Peripheral Nerve Injuries | - |
dc.subject | Sciatic Nerve | - |
dc.subject | Sensory Receptor Cells | - |
dc.subject | Vascular Endothelial Growth Factor A | - |
dc.title | Activating Injury-Responsive Genes with Hypoxia Enhances Axon Regeneration through Neuronal HIF-1α | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Y. | - |
dc.contributor.affiliatedAuthor | Shin, J.E. | - |
dc.identifier.doi | 10.1016/j.neuron.2015.09.050 | - |
dc.identifier.scopusid | 2-s2.0-84960121270 | - |
dc.identifier.bibliographicCitation | Neuron, v.88, no.4, pp.720 - 734 | - |
dc.relation.isPartOf | Neuron | - |
dc.citation.title | Neuron | - |
dc.citation.volume | 88 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 720 | - |
dc.citation.endPage | 734 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | hypoxia inducible factor 1alpha | - |
dc.subject.keywordPlus | vasculotropin A | - |
dc.subject.keywordPlus | Hif1a protein, mouse | - |
dc.subject.keywordPlus | hypoxia inducible factor 1alpha | - |
dc.subject.keywordPlus | vascular endothelial growth factor A, mouse | - |
dc.subject.keywordPlus | vasculotropin A | - |
dc.subject.keywordPlus | animal cell | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | cell hypoxia | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | embryo | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | gene silencing | - |
dc.subject.keywordPlus | in vitro study | - |
dc.subject.keywordPlus | in vivo study | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | motoneuron | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | muscle reinnervation | - |
dc.subject.keywordPlus | nerve cell lesion | - |
dc.subject.keywordPlus | nerve fiber regeneration | - |
dc.subject.keywordPlus | neuromuscular synapse | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | protein expression | - |
dc.subject.keywordPlus | sensory nerve cell | - |
dc.subject.keywordPlus | transcription regulation | - |
dc.subject.keywordPlus | upregulation | - |
dc.subject.keywordPlus | animal | - |
dc.subject.keywordPlus | axon | - |
dc.subject.keywordPlus | cell culture | - |
dc.subject.keywordPlus | cytology | - |
dc.subject.keywordPlus | gene expression regulation | - |
dc.subject.keywordPlus | genetics | - |
dc.subject.keywordPlus | hypoxia | - |
dc.subject.keywordPlus | injuries | - |
dc.subject.keywordPlus | metabolism | - |
dc.subject.keywordPlus | nerve regeneration | - |
dc.subject.keywordPlus | neuromuscular junction | - |
dc.subject.keywordPlus | peripheral nerve injury | - |
dc.subject.keywordPlus | sciatic nerve | - |
dc.subject.keywordPlus | sensory nerve cell | - |
dc.subject.keywordPlus | spinal ganglion | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Axons | - |
dc.subject.keywordPlus | Cells, Cultured | - |
dc.subject.keywordPlus | Ganglia, Spinal | - |
dc.subject.keywordPlus | Gene Expression Regulation | - |
dc.subject.keywordPlus | Gene Knockdown Techniques | - |
dc.subject.keywordPlus | Hypoxia | - |
dc.subject.keywordPlus | Hypoxia-Inducible Factor 1, alpha Subunit | - |
dc.subject.keywordPlus | In Vitro Techniques | - |
dc.subject.keywordPlus | Mice | - |
dc.subject.keywordPlus | Motor Neurons | - |
dc.subject.keywordPlus | Nerve Regeneration | - |
dc.subject.keywordPlus | Neuromuscular Junction | - |
dc.subject.keywordPlus | Peripheral Nerve Injuries | - |
dc.subject.keywordPlus | Sciatic Nerve | - |
dc.subject.keywordPlus | Sensory Receptor Cells | - |
dc.subject.keywordPlus | Vascular Endothelial Growth Factor A | - |
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