Activating Injury-Responsive Genes with Hypoxia Enhances Axon Regeneration through Neuronal HIF-1α
- Authors
- Cho, Y.; Shin, J.E.; Ewan, E.E.; Oh, Y.M.; Pita-Thomas, W.; Cavalli, V.
- Issue Date
- 2015
- Publisher
- Cell Press
- Citation
- Neuron, v.88, no.4, pp.720 - 734
- Indexed
- SCIE
SCOPUS
- Journal Title
- Neuron
- Volume
- 88
- Number
- 4
- Start Page
- 720
- End Page
- 734
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/95888
- DOI
- 10.1016/j.neuron.2015.09.050
- ISSN
- 0896-6273
- Abstract
- Injured peripheral neurons successfully activate a proregenerative transcriptional program to enable axon regeneration and functional recovery. How transcriptional regulators coordinate the expression of such program remains unclear. Here we show that hypoxia-inducible factor 1α (HIF-1α) controls multiple injury-induced genes in sensory neurons and contribute to the preconditioning lesion effect. Knockdown of HIF-1α in vitro or conditional knock out in vivo impairs sensory axon regeneration. The HIF-1α target gene Vascular Endothelial Growth Factor A (VEGFA) is expressed in injured neurons and contributes to stimulate axon regeneration. Induction of HIF-1α using hypoxia enhances axon regeneration in vitro and in vivo in sensory neurons. Hypoxia also stimulates motor neuron regeneration and accelerates neuromuscular junction re-innervation. This study demonstrates that HIF-1α represents a critical transcriptional regulator in regenerating neurons and suggests hypoxia as a tool to stimulate axon regeneration. © 2015 Elsevier Inc.
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Collections - Graduate School > Department of Life Sciences > 1. Journal Articles
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