One step synthesis of quantum dot-magnetic nanoparticle heterodimers for dual modal imaging applications
- Authors
- Lee, J.; Hwang, G.; Hong, Y.S.; Sim, T.
- Issue Date
- 2015
- Publisher
- Royal Society of Chemistry
- Citation
- Analyst, v.140, no.8, pp.2864 - 2868
- Indexed
- SCIE
SCOPUS
- Journal Title
- Analyst
- Volume
- 140
- Number
- 8
- Start Page
- 2864
- End Page
- 2868
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/95917
- DOI
- 10.1039/c4an02322f
- ISSN
- 0003-2654
- Abstract
- Dual modal nanoprobes are promising tools for accurately detecting target molecules as part of the diagnosis of diseases including cancers. We have explored a new dual modal bioimaging probe that is comprised of a quantum dot (QD)-magnetic nanoparticle (MNP) hybrid. The MNP-QD heterodimers explored are fabricated by using a platinum-guanine coordination bonding guided self-assembly process, employing the metal-DNA conjugation method. Investigations utilizing energy dispersive spectroscopy (EDS) equipped high resolution transmission electron microscopy (HRTEM) demonstrate that the heterodimer contains an iron (Fe) dominant MNP and a cadmium (Cd) dominant QD. Finally, the results of cell studies show that the MNP-QD conjugates display good HeLa cell uptake in the absence of non-specific binding to the cell membrane and, as such, they can be used to label cells in vitro and in vivo as part of a new cell imaging technique. This journal is © The Royal Society of Chemistry 2015.
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Collections - Graduate School > KU-KIST Graduate School of Converging Science and Technology > 1. Journal Articles
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