Alendronate-Eluting Biphasic Calcium Phosphate (BCP) Scaffolds Stimulate Osteogenic Differentiation
DC Field | Value | Language |
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dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Yun, Young-Pil | - |
dc.contributor.author | Lee, Deok-Won | - |
dc.contributor.author | Kang, Eun Young | - |
dc.contributor.author | Jeong, Won Jae | - |
dc.contributor.author | Lee, Boram | - |
dc.contributor.author | Jeong, Myeong Seon | - |
dc.contributor.author | Kim, Hak Jun | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Song, Hae-Ryong | - |
dc.date.accessioned | 2021-09-05T00:18:39Z | - |
dc.date.available | 2021-09-05T00:18:39Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2314-6133 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/96110 | - |
dc.description.abstract | Biphasic calcium phosphate (BCP) scaffolds have been widely used in orthopedic and dental fields as osteoconductive bone substitutes. However, BCP scaffolds are not satisfactory for the stimulation of osteogenic differentiation and maturation. To enhance osteogenic differentiation, we prepared alendronate- (ALN-) eluting BCP scaffolds. The coating of ALN on BCP scaffolds was confirmed by scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDS), and attenuated total reflectance-Fourier transforminfrared spectroscopy (ATR-FTIR). An in vitro release study showed that release of ALN from ALN-eluting BCP scaffolds was sustained for up to 28 days. In vitro results revealed that MG-63 cells grown on ALN- eluting BCP scaffolds exhibited increased ALP activity and calcium deposition and upregulated gene expression of Runx2, ALP, OCN, and OPN compared with the BCP scaffold alone. Therefore, this study suggests that ALN-eluting BCP scaffolds have the potential to effectively stimulate osteogenic differentiation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI LTD | - |
dc.subject | OSTEOBLAST PROLIFERATION | - |
dc.subject | BONE REGENERATION | - |
dc.subject | STEM-CELLS | - |
dc.subject | IN-VITRO | - |
dc.subject | BISPHOSPHONATES | - |
dc.subject | BIOCERAMICS | - |
dc.subject | EXPRESSION | - |
dc.subject | DELIVERY | - |
dc.subject | ENHANCEMENT | - |
dc.subject | INHIBITION | - |
dc.title | Alendronate-Eluting Biphasic Calcium Phosphate (BCP) Scaffolds Stimulate Osteogenic Differentiation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hak Jun | - |
dc.contributor.affiliatedAuthor | Song, Hae-Ryong | - |
dc.identifier.doi | 10.1155/2015/320713 | - |
dc.identifier.scopusid | 2-s2.0-84937010614 | - |
dc.identifier.wosid | 000357786600001 | - |
dc.identifier.bibliographicCitation | BIOMED RESEARCH INTERNATIONAL, v.2015 | - |
dc.relation.isPartOf | BIOMED RESEARCH INTERNATIONAL | - |
dc.citation.title | BIOMED RESEARCH INTERNATIONAL | - |
dc.citation.volume | 2015 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | OSTEOBLAST PROLIFERATION | - |
dc.subject.keywordPlus | BONE REGENERATION | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | BISPHOSPHONATES | - |
dc.subject.keywordPlus | BIOCERAMICS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | ENHANCEMENT | - |
dc.subject.keywordPlus | INHIBITION | - |
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