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Alendronate-Eluting Biphasic Calcium Phosphate (BCP) Scaffolds Stimulate Osteogenic Differentiation

Authors
Kim, Sung EunYun, Young-PilLee, Deok-WonKang, Eun YoungJeong, Won JaeLee, BoramJeong, Myeong SeonKim, Hak JunPark, KyeongsoonSong, Hae-Ryong
Issue Date
2015
Publisher
HINDAWI LTD
Citation
BIOMED RESEARCH INTERNATIONAL, v.2015
Indexed
SCIE
SCOPUS
Journal Title
BIOMED RESEARCH INTERNATIONAL
Volume
2015
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/96110
DOI
10.1155/2015/320713
ISSN
2314-6133
Abstract
Biphasic calcium phosphate (BCP) scaffolds have been widely used in orthopedic and dental fields as osteoconductive bone substitutes. However, BCP scaffolds are not satisfactory for the stimulation of osteogenic differentiation and maturation. To enhance osteogenic differentiation, we prepared alendronate- (ALN-) eluting BCP scaffolds. The coating of ALN on BCP scaffolds was confirmed by scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDS), and attenuated total reflectance-Fourier transforminfrared spectroscopy (ATR-FTIR). An in vitro release study showed that release of ALN from ALN-eluting BCP scaffolds was sustained for up to 28 days. In vitro results revealed that MG-63 cells grown on ALN- eluting BCP scaffolds exhibited increased ALP activity and calcium deposition and upregulated gene expression of Runx2, ALP, OCN, and OPN compared with the BCP scaffold alone. Therefore, this study suggests that ALN-eluting BCP scaffolds have the potential to effectively stimulate osteogenic differentiation.
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College of Medicine > Department of Medical Science > 1. Journal Articles
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