The Polymorphisms K469E and G261R of Intercellular Adhesion Molecule-1 and Susceptibility to Inflammatory Bowel Disease: A Meta-Analysis
DC Field | Value | Language |
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dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-05T00:58:52Z | - |
dc.date.available | 2021-09-05T00:58:52Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0882-0139 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/96223 | - |
dc.description.abstract | Objective: The aim of this study was to explore whether polymorphisms of intercellular adhesion molecule-1 (ICAM-1) are associated with susceptibility to Crohn's disease (CD) and ulcerative colitis (UC). Methods: The authors conducted a meta-analysis on the associations between the polymorphisms K469E and G241R of ICAM-1 and susceptibility to CD and UC. Results: A total of 8 studies with 801 patients with CD, 672 patients with UC, and 1,828 controls were included in the meta-analysis. The meta-analysis revealed no association between CD and the ICAM-1 469E allele among the subjects (OR = 1.175, 95% CI = 0.901-1.533, p = 0.233). However, stratification by ethnicity indicated an association between the ICAM-1 469E allele and CD in Europeans (OR = 1.425, 95% CI = 1.013-2.002, p = 0.042). Meta-analysis using the homozygosity also showed an association with CD in Europeans (OR = 2.054, 95% CI = 1.036-4.073, p = 0.039). The meta-analysis revealed no association between UC and the ICAM-1 K469E polymorphism. No association between CD or UC and the ICAM-1 G241R polymorphism was observed. Conclusions: This meta-analysis demonstrates that the ICAM-1 K469E polymorphism may be associated with susceptibility to CD in Europeans, but no association was found between ICAM-1 K469E and UC. In contrast, the G241R polymorphism was not found to be associated with susceptibility to either CD or UC. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | INFORMA HEALTHCARE | - |
dc.subject | GENE POLYMORPHISMS | - |
dc.subject | BEHCETS-DISEASE | - |
dc.subject | ICAM-1 GENE | - |
dc.subject | ASSOCIATION | - |
dc.subject | SELECTIN | - |
dc.title | The Polymorphisms K469E and G261R of Intercellular Adhesion Molecule-1 and Susceptibility to Inflammatory Bowel Disease: A Meta-Analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.3109/08820139.2015.1010685 | - |
dc.identifier.scopusid | 2-s2.0-84928892746 | - |
dc.identifier.wosid | 000353918800004 | - |
dc.identifier.bibliographicCitation | IMMUNOLOGICAL INVESTIGATIONS, v.44, no.4, pp.361 - 372 | - |
dc.relation.isPartOf | IMMUNOLOGICAL INVESTIGATIONS | - |
dc.citation.title | IMMUNOLOGICAL INVESTIGATIONS | - |
dc.citation.volume | 44 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 361 | - |
dc.citation.endPage | 372 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | BEHCETS-DISEASE | - |
dc.subject.keywordPlus | ICAM-1 GENE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | SELECTIN | - |
dc.subject.keywordAuthor | Crohn&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | ICAM-1 | - |
dc.subject.keywordAuthor | meta-analysis | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | ulcerative colitis | - |
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