The Polymorphisms K469E and G261R of Intercellular Adhesion Molecule-1 and Susceptibility to Inflammatory Bowel Disease: A Meta-Analysis
- Authors
- Song, Gwan Gyu; Lee, Young Ho
- Issue Date
- 2015
- Publisher
- INFORMA HEALTHCARE
- Keywords
- Crohn' s disease; ICAM-1; meta-analysis; polymorphism; ulcerative colitis
- Citation
- IMMUNOLOGICAL INVESTIGATIONS, v.44, no.4, pp.361 - 372
- Indexed
- SCIE
SCOPUS
- Journal Title
- IMMUNOLOGICAL INVESTIGATIONS
- Volume
- 44
- Number
- 4
- Start Page
- 361
- End Page
- 372
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/96223
- DOI
- 10.3109/08820139.2015.1010685
- ISSN
- 0882-0139
- Abstract
- Objective: The aim of this study was to explore whether polymorphisms of intercellular adhesion molecule-1 (ICAM-1) are associated with susceptibility to Crohn's disease (CD) and ulcerative colitis (UC). Methods: The authors conducted a meta-analysis on the associations between the polymorphisms K469E and G241R of ICAM-1 and susceptibility to CD and UC. Results: A total of 8 studies with 801 patients with CD, 672 patients with UC, and 1,828 controls were included in the meta-analysis. The meta-analysis revealed no association between CD and the ICAM-1 469E allele among the subjects (OR = 1.175, 95% CI = 0.901-1.533, p = 0.233). However, stratification by ethnicity indicated an association between the ICAM-1 469E allele and CD in Europeans (OR = 1.425, 95% CI = 1.013-2.002, p = 0.042). Meta-analysis using the homozygosity also showed an association with CD in Europeans (OR = 2.054, 95% CI = 1.036-4.073, p = 0.039). The meta-analysis revealed no association between UC and the ICAM-1 K469E polymorphism. No association between CD or UC and the ICAM-1 G241R polymorphism was observed. Conclusions: This meta-analysis demonstrates that the ICAM-1 K469E polymorphism may be associated with susceptibility to CD in Europeans, but no association was found between ICAM-1 K469E and UC. In contrast, the G241R polymorphism was not found to be associated with susceptibility to either CD or UC.
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