Hepatoprotective Activity of Water Extracts from Chaga Medicinal Mushroom, Inonotus obliquus (Higher Basidiomycetes) Against Tert-Butyl Hydroperoxide-Induced Oxidative Liver Injury in Primary Cultured Rat Hepatocytes
DC Field | Value | Language |
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dc.contributor.author | Hong, Ki-Bae | - |
dc.contributor.author | Noh, Dong Ouk | - |
dc.contributor.author | Park, Yooheon | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.date.accessioned | 2021-09-05T01:10:21Z | - |
dc.date.available | 2021-09-05T01:10:21Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1521-9437 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/96309 | - |
dc.description.abstract | We examined the hepatoprotective activity of Inonotus obliquus water extract (IO-W) against tertbutyl hydroperoxide (t-BHP)-induced oxidative liver injury in the primary cultured rat hepatocyte. The 50% radical scavenging concentrations (SC(50)s) of IO-W for radical-scavenging activity against 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 1,1-diphenyl-2-picryl-hydrazyl (DPPH) were 5.19 mg/mL and 0.39 mg/mL, respectively. IO-W pretreatment to the primary cultured hepatocytes significantly (p<0.05) protected the cells from t-BHP-induced cytotoxic injury even at a low concentration of IO-W (10 mu g/mL). The cellular leakage of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH), as well as malondialdehyde (MDA) formation caused by t-BHP were significantly (p<0.05) suppressed by IO-W pretreatment (>100 mu g/mL). In conclusion, this study demonstrates that IO-W exhibited hepatoprotective activity against t-BHP-induced oxidative liver injury in the primary cultured hepatocyte probably via its abilities of quenching free radicals, inhibiting the leakage of ALT, AST, and LDH, and decreasing MDA formation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BEGELL HOUSE INC | - |
dc.subject | ANTIOXIDANT ACTIVITY | - |
dc.subject | LIPID-PEROXIDATION | - |
dc.subject | PHENOLIC-COMPOUNDS | - |
dc.subject | CELL-DEATH | - |
dc.subject | PRODUCTS | - |
dc.subject | PLANTS | - |
dc.subject | ASSAY | - |
dc.subject | CYTOTOXICITY | - |
dc.subject | SUBSTANCES | - |
dc.subject | METABOLISM | - |
dc.title | Hepatoprotective Activity of Water Extracts from Chaga Medicinal Mushroom, Inonotus obliquus (Higher Basidiomycetes) Against Tert-Butyl Hydroperoxide-Induced Oxidative Liver Injury in Primary Cultured Rat Hepatocytes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.1615/IntJMedMushrooms.v17.i11.70 | - |
dc.identifier.scopusid | 2-s2.0-84955438374 | - |
dc.identifier.wosid | 000368922700007 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS, v.17, no.11, pp.1069 - 1076 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS | - |
dc.citation.volume | 17 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1069 | - |
dc.citation.endPage | 1076 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Mycology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Mycology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTIVITY | - |
dc.subject.keywordPlus | LIPID-PEROXIDATION | - |
dc.subject.keywordPlus | PHENOLIC-COMPOUNDS | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | PRODUCTS | - |
dc.subject.keywordPlus | PLANTS | - |
dc.subject.keywordPlus | ASSAY | - |
dc.subject.keywordPlus | CYTOTOXICITY | - |
dc.subject.keywordPlus | SUBSTANCES | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordAuthor | medicinal mushrooms | - |
dc.subject.keywordAuthor | Inonotus obliquus | - |
dc.subject.keywordAuthor | Chaga mushroom | - |
dc.subject.keywordAuthor | hepatocyte | - |
dc.subject.keywordAuthor | tert-butyl hydroperoxide | - |
dc.subject.keywordAuthor | primary culture | - |
dc.subject.keywordAuthor | liver injury | - |
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