Hypocholesterolemic Effects of the Cauliflower Culinary-Medicinal Mushroom, Sparassis crispa (Higher Basidiomycetes), in Diet-Induced Hypercholesterolemic Rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Ki Bae | - |
dc.contributor.author | Hong, Sung-Yong | - |
dc.contributor.author | Joung, Eun Young | - |
dc.contributor.author | Kim, Byung Hee | - |
dc.contributor.author | Bae, Song-Hwan | - |
dc.contributor.author | Park, Yooheon | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.date.accessioned | 2021-09-05T01:10:27Z | - |
dc.date.available | 2021-09-05T01:10:27Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1521-9437 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/96310 | - |
dc.description.abstract | The cauliflower culinary-medicinal mushroom, Sparassis crispa, possesses various biological activities that have been widely reported to have therapeutic applications. We examined the effects of S. crispa on serum cholesterol, hepatic enzymes related to cholesterol metabolism, and fecal sterol excretion in rats fed a cholesterol-rich diet for 4 weeks. Male Sprague-Dawley rats (8 weeks old) were randomly divided into 5 groups (n = 6 mice per group): normal diet (normal control [NC]), cholesterol-rich diet (cholesterol control [ CC]), cholesterol-rich diet plus S. crispa fruiting body (SC), cholesterol-rich diet plus S. crispa extract (SCE), and cholesterol-rich diet plus S. crispa residue (SCR). SCE supplementation significantly enhanced hepatic cholesterol catabolism through the upregulation of cholesterol 7 alpha-hydroxylase (CYP7A1) messenger RNA (mRNA) expression (2.55-fold compared with that in the NC group; P < 0.05) and the downregulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase mRNA expression (0.57-fold compared with that in the NC group; P < 0.05). Additionally, the SCE diet resulted in the highest fecal excretion of cholesterol and bile acid in hypercholesterolemic rats. In conclusion, mRNA expression of CYP7A1 and HMG-CoA reductase were significantly modulated by the absorption of SCE samples. Also, SCE samples had a significant effect on fecal bile acid and cholesterol excretion. These results suggest that SCE samples can induce hypocholesterolic effects through cholesterol metabolism and the reduction of circulating cholesterol levels. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BEGELL HOUSE INC | - |
dc.subject | BILE-ACID HOMEOSTASIS | - |
dc.subject | BARLEY BETA-GLUCAN | - |
dc.subject | BLOOD-LIPIDS | - |
dc.subject | OAT BRAN | - |
dc.subject | CHOLESTEROL | - |
dc.subject | BIOSYNTHESIS | - |
dc.subject | EXPRESSION | - |
dc.subject | DECREASE | - |
dc.subject | FRACTION | - |
dc.subject | ENZYMES | - |
dc.title | Hypocholesterolemic Effects of the Cauliflower Culinary-Medicinal Mushroom, Sparassis crispa (Higher Basidiomycetes), in Diet-Induced Hypercholesterolemic Rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.1615/IntJMedMushrooms.v17.i10.60 | - |
dc.identifier.scopusid | 2-s2.0-84955577923 | - |
dc.identifier.wosid | 000368097100007 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS, v.17, no.10, pp.965 - 975 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS | - |
dc.citation.volume | 17 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 965 | - |
dc.citation.endPage | 975 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Mycology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Mycology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | BILE-ACID HOMEOSTASIS | - |
dc.subject.keywordPlus | BARLEY BETA-GLUCAN | - |
dc.subject.keywordPlus | BLOOD-LIPIDS | - |
dc.subject.keywordPlus | OAT BRAN | - |
dc.subject.keywordPlus | CHOLESTEROL | - |
dc.subject.keywordPlus | BIOSYNTHESIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DECREASE | - |
dc.subject.keywordPlus | FRACTION | - |
dc.subject.keywordPlus | ENZYMES | - |
dc.subject.keywordAuthor | medicinal mushrooms | - |
dc.subject.keywordAuthor | Sparassis crispa | - |
dc.subject.keywordAuthor | hypercholesterolemia | - |
dc.subject.keywordAuthor | cholesterol | - |
dc.subject.keywordAuthor | cholesterol 7 alpha-hydroxylase | - |
dc.subject.keywordAuthor | 3-hydroxy-3-methylglutaryl coenzyme A | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.