Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Apolipoprotein E4 Affects Topographical Changes in Hippocampal and Cortical Atrophy in Alzheimer's Disease Dementia: A Five-Year Longitudinal Study

Authors
Kim, Yeo JinCho, HannaKim, Yun JoongKi, Chang-SeokChung, Sun JuYe, Byoung SeokKim, Hee JinKim, Jung-HyunKim, Sung TaeLee, Kyung HanJeon, SeunLee, Jong-MinChin, JuheeKim, Jeong-HunNa, Duk L.Seong, Joon-KyungSeo, Sang Won
Issue Date
2015
Publisher
IOS PRESS
Keywords
APOE4 allele; cortical thickness; dementia with Alzheimer' s disease; hippocampal deformities; longitudinal study
Citation
JOURNAL OF ALZHEIMERS DISEASE, v.44, no.4, pp.1075 - 1085
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF ALZHEIMERS DISEASE
Volume
44
Number
4
Start Page
1075
End Page
1085
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/96405
DOI
10.3233/JAD-141773
ISSN
1387-2877
Abstract
Apolipoprotein E4 (APOE4) is a genetic risk factor for developing Alzheimer's disease (AD). Once AD manifests clinically, however, the effects of APOE4 are less clear. Therefore, we investigated the longitudinal effects of APOE4 on topographical changes in AD patient brain atrophy. We prospectively recruited 35 patients with AD (19 APOE4 carriers and 16 non-carriers), and 14 normal controls, then followed them for five years. We measured hippocampal deformities and cortical thickness. Hippocampal comparison between APOE4 carriers and non-carriers with AD showed carriers had rapid changes in the head and body, while non-carriers had rapid changes in a small portion of the body. Cortical thickness comparison between APOE4 carriers and non-carriers with AD dementia showed carriers had rapid thinning in the lateral frontal, temporal, and parietal regions, while no region showed more rapid cortical thinning in non-carriers than in carriers. These findings underlined the importance of the APOE4 allele for designing and interpreting future treatment trials in patients with AD dementia.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Artificial Intelligence > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE