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Application of Response Surface Methodology to Optimize the Extraction of Acetylcholinesterase Inhibitors from Rhodiola sachalinensis

Authors
Kim, Cho RongKim, Jae KyeomShin, Eui-CheolChoi, Soo JungKwon, Yoon KyungKim, Youn-JungKim, Chang-JuPark, Gwi GunPark, Cheung-SeogShin, Dong-Hoon
Issue Date
12월-2014
Publisher
KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
Keywords
acetylcholinesterase; Alzheimer' s disease; response surface methodology; Rhodiola sachalinensis; roseroot
Citation
JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, v.57, no.6, pp.807 - 811
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY
Volume
57
Number
6
Start Page
807
End Page
811
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/96598
DOI
10.1007/s13765-014-4293-8
ISSN
1738-2203
Abstract
Response surface methodology (RSM) was utilized to optimize extraction conditions for the acetylcholinesterase inhibitor from Rhodiola sachalinensis. Optimized values for AChE inhibition and extraction yield were 19.41 and 13.35%, respectively, and these were in good agreement with the experimental values from validation, suggesting that RSM is a useful tool.
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