Effects of Capsaicin on Adipogenic Differentiation in Bovine Bone Marrow Mesenchymal Stem Cell
DC Field | Value | Language |
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dc.contributor.author | Jeong, Jin Young | - |
dc.contributor.author | Suresh, Sekar | - |
dc.contributor.author | Park, Mi Na | - |
dc.contributor.author | Jang, Mi | - |
dc.contributor.author | Park, Sungkwon | - |
dc.contributor.author | Gobianand, Kuppannan | - |
dc.contributor.author | You, Seungkwon | - |
dc.contributor.author | Yeon, Sung-Heom | - |
dc.contributor.author | Lee, Hyun-Jeong | - |
dc.date.accessioned | 2021-09-05T02:40:59Z | - |
dc.date.available | 2021-09-05T02:40:59Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-12 | - |
dc.identifier.issn | 1011-2367 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/96705 | - |
dc.description.abstract | Capsaicin is a major constituent of hot chili peppers that influences lipid metabolism in animals. In this study, we explored the effects of capsaicin on adipogenic differentiation of bovine bone marrow mesenchymal stem cells (BMSCs) in a dose- and time-dependent manner. The BMSCs were treated with various concentrations of capsaicin (0, 0.1, 1, 5, and 10 mu M) for 2, 4, and 6 days. Capsaicin suppressed fat deposition significantly during adipogenic differentiation. Peroxisome proliferator-activated receptor gamma, cytosine-cytosine-adenosine-adenosine-thymidine/enhancer binding protein alpha, fatty acid binding protein 4, and stearoyl-CoA desaturase expression decreased after capsaicin treatment. We showed that the number of apoptotic cells increased in dose- and time-dependent manners. Furthermore, we found that capsaicin increased the expression levels of apoptotic genes, such as B-cell lymphoma 2-associated X protein and caspase 3. Overall, capsaicin inhibits fat deposition by triggering apoptosis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ASIAN-AUSTRALASIAN ASSOC ANIMAL PRODUCTION SOC | - |
dc.subject | HEPATIC STELLATE CELL | - |
dc.subject | STROMAL CELLS | - |
dc.subject | CANCER-CELLS | - |
dc.subject | ADIPOCYTE DIFFERENTIATION | - |
dc.subject | FAT DEPOSITION | - |
dc.subject | ADIPOSE-TISSUE | - |
dc.subject | APOPTOSIS | - |
dc.subject | MUSCLE | - |
dc.subject | GAMMA | - |
dc.subject | ACTIVATION | - |
dc.title | Effects of Capsaicin on Adipogenic Differentiation in Bovine Bone Marrow Mesenchymal Stem Cell | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | You, Seungkwon | - |
dc.identifier.doi | 10.5713/ajas.2014.14720 | - |
dc.identifier.scopusid | 2-s2.0-84908485609 | - |
dc.identifier.wosid | 000344219700016 | - |
dc.identifier.bibliographicCitation | ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, v.27, no.12, pp.1783 - 1793 | - |
dc.relation.isPartOf | ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES | - |
dc.citation.title | ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES | - |
dc.citation.volume | 27 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1783 | - |
dc.citation.endPage | 1793 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001927594 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Dairy & Animal Science | - |
dc.subject.keywordPlus | HEPATIC STELLATE CELL | - |
dc.subject.keywordPlus | STROMAL CELLS | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | ADIPOCYTE DIFFERENTIATION | - |
dc.subject.keywordPlus | FAT DEPOSITION | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | MUSCLE | - |
dc.subject.keywordPlus | GAMMA | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | Bovine Bone Marrow Mesenchymal Stem Cells [BMSCs] | - |
dc.subject.keywordAuthor | Capsaicin | - |
dc.subject.keywordAuthor | Adipogenesis | - |
dc.subject.keywordAuthor | Differentiation | - |
dc.subject.keywordAuthor | Apoptosis | - |
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