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Effects of Capsaicin on Adipogenic Differentiation in Bovine Bone Marrow Mesenchymal Stem Cell

Authors
Jeong, Jin YoungSuresh, SekarPark, Mi NaJang, MiPark, SungkwonGobianand, KuppannanYou, SeungkwonYeon, Sung-HeomLee, Hyun-Jeong
Issue Date
12월-2014
Publisher
ASIAN-AUSTRALASIAN ASSOC ANIMAL PRODUCTION SOC
Keywords
Bovine Bone Marrow Mesenchymal Stem Cells [BMSCs]; Capsaicin; Adipogenesis; Differentiation; Apoptosis
Citation
ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, v.27, no.12, pp.1783 - 1793
Indexed
SCIE
SCOPUS
KCI
Journal Title
ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES
Volume
27
Number
12
Start Page
1783
End Page
1793
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/96705
DOI
10.5713/ajas.2014.14720
ISSN
1011-2367
Abstract
Capsaicin is a major constituent of hot chili peppers that influences lipid metabolism in animals. In this study, we explored the effects of capsaicin on adipogenic differentiation of bovine bone marrow mesenchymal stem cells (BMSCs) in a dose- and time-dependent manner. The BMSCs were treated with various concentrations of capsaicin (0, 0.1, 1, 5, and 10 mu M) for 2, 4, and 6 days. Capsaicin suppressed fat deposition significantly during adipogenic differentiation. Peroxisome proliferator-activated receptor gamma, cytosine-cytosine-adenosine-adenosine-thymidine/enhancer binding protein alpha, fatty acid binding protein 4, and stearoyl-CoA desaturase expression decreased after capsaicin treatment. We showed that the number of apoptotic cells increased in dose- and time-dependent manners. Furthermore, we found that capsaicin increased the expression levels of apoptotic genes, such as B-cell lymphoma 2-associated X protein and caspase 3. Overall, capsaicin inhibits fat deposition by triggering apoptosis.
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생명과학대학 (생명공학부)
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