Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Amyotrophic Lateral Sclerosis and Agricultural Environments: A Systematic Review

Authors
Kang, HyunCha, Eun ShilChoi, Geun JooLee, Won Jin
Issue Date
12월-2014
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
Agriculture; Environmental Exposure; Farming; Meta-analysis; Neurodegenerative Diseases; Occupations
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.29, no.12, pp.1610 - 1617
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
29
Number
12
Start Page
1610
End Page
1617
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/96724
DOI
10.3346/jkms.2014.29.12.1610
ISSN
1011-8934
Abstract
The aim of this study was to examine the relationship between the risk of amyotrophic lateral sclerosis (ALS) and exposure to rural environments. Studies were identified through OVID MEDLINE and EMBASE search up to September 2013 using as keywords rural residence, farmers, and pesticide exposure. Twenty-two studies were included for this meta-analysis. Summary odds ratios (ORs) were calculated using random effect model by type of exposure index, and subgroup analyses were conducted according to study design, gender, region, case ascertainment, and exposure assessment. The risk of ALS was significantly increased with pesticide exposure (OR, 1.44; 95% CI, 1.22-1.70) and with farmers (OR, 1.42; 95% CI, 1.17-1.73), but was not significant with rural residence (OR, 1.25; 95% CI, 0.84-1.87). The risk estimates for subgroup analysis between pesticide exposure and ALS indicated a significant positive association with men (OR, 1.96), and in studies using El Escorial criteria for ALS definition (OR, 1.63) and expert judgment for pesticide exposure (OR, 2.04) as well. No significant publication bias was observed. Our findings support the association of pesticide exposure and an increased risk for ALS, stressing that the use of more specific exposure information resulted in more significant associations.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Biomedical Sciences > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lee, Won Jin photo

Lee, Won Jin
의과학과
Read more

Altmetrics

Total Views & Downloads

BROWSE