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Osteoblast activity of MG-63 cells is enhanced by growth on a lactoferrin-immobilized titanium substrate
- Issue Date
- 1-11월-2014
- Publisher
- ELSEVIER
- Keywords
- Titanium; Lactoferrin; Heparin-dopamine; Osteoblast; Osteogenic differentiation
- Citation
- COLLOIDS AND SURFACES B-BIOINTERFACES, v.123, pp.191 - 198
- Indexed
- SCIE
SCOPUS
- Journal Title
- COLLOIDS AND SURFACES B-BIOINTERFACES
- Volume
- 123
- Start Page
- 191
- End Page
- 198
- ISSN
- 0927-7765
- Abstract
- The aim of this study was to develop a lactoferrin (LF)-immobilized titanium (Ti) substrate to enhance the osteoblast activity of MG-63 cells. Ti substrates were first modified through heparin-dopamine (Hep-DOPA) anchorage. Then, LF was immobilized on the Hep-Ti substrates via electrostatic interactions. Hep-Ti substrates, with or without LF, were evaluated by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and contact angle measurements. Sustained release of LF on the Ti substrates was observed over a 28-day period. In vitro studies of osteoblast activity showed increased alkaline phosphatase activity and calcium deposition by MG-63 cells cultured on LF-immobilized Ti substrates as compared to those cultured on pristine Ti substrates, indicating that LF-immobilized Ti substrates were effective at enhancing osteoblast activity. (C) 2014 Elsevier B.V. All rights reserved.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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