Epidemiology and clinical features of toxigenic culture-confirmed hospital-onset Clostridium difficile infection: a multicentre prospective study in tertiary hospitals of South Korea
DC Field | Value | Language |
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dc.contributor.author | Han, Sang Hoon | - |
dc.contributor.author | Kim, Heejung | - |
dc.contributor.author | Lee, Kyungwon | - |
dc.contributor.author | Jeong, Su Jin | - |
dc.contributor.author | Park, Ki-Ho | - |
dc.contributor.author | Song, Joon Young | - |
dc.contributor.author | Seo, Yu Bin | - |
dc.contributor.author | Choi, Jun Yong | - |
dc.contributor.author | Woo, Jun Hee | - |
dc.contributor.author | Kim, Woo Joo | - |
dc.contributor.author | Kim, June Myung | - |
dc.date.accessioned | 2021-09-05T03:18:13Z | - |
dc.date.available | 2021-09-05T03:18:13Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-11 | - |
dc.identifier.issn | 0022-2615 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/96846 | - |
dc.description.abstract | Hypervirulent Clostridium difficile strains, most notably BI/NAP1/027, have been increasingly emerging in Western countries as local epidemics. We performed a prospective multicentre observational study from December 2011 to May 2012 to identify recent incidences of toxigenic culture-confirmed hospital-onset C. difficile infections (CD!) and their associated clinical characteristics in South Korea. Patients suspected of having been suffering from CDI more than 48 h after admission and aged >= 20 years were prospectively enrolled and provided loose stool specimens Toxigenic C. difficile culture (anaerobic cultured-toxin A/B/binary gene PCR) and PCR ribotyping were performed in one central laboratory. We enrolled 98 toxigenic cultureconfirmed CDI-infected patients and 250 toxigenic culture-negative participants from three hospitals. The incidence of toxigenic culture-confirmed hospital-onset CU cases was 2.7 per 10 000 patient-days. The percentage of severe CD' cases was relatively low at only 3.1 %. UK ribotype 018 was the predominant type (48.1%). There were no hypervirulent BI/NAP1/027 isolates identified. The independent risk factors for toxigenic culture-confirmed hospital-onset CDI were invasive procedure (odds ratio (OR) 7.3, P=0.003) and past CDI history within 3 months (OR 28.5, P=0.003). In conclusion, the incidence and severity of CDI in our study were not higher than reported in Western countries. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MICROBIOLOGY SOC | - |
dc.subject | POLYMERASE-CHAIN-REACTION | - |
dc.subject | PCR RIBOTYPE 027 | - |
dc.subject | BINARY TOXIN | - |
dc.subject | RISK-FACTORS | - |
dc.subject | PSEUDOMEMBRANOUS COLITIS | - |
dc.subject | ACINETOBACTER SPP. | - |
dc.subject | DIARRHEA | - |
dc.subject | DIAGNOSIS | - |
dc.subject | STRAIN | - |
dc.subject | SURVEILLANCE | - |
dc.title | Epidemiology and clinical features of toxigenic culture-confirmed hospital-onset Clostridium difficile infection: a multicentre prospective study in tertiary hospitals of South Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Joon Young | - |
dc.contributor.affiliatedAuthor | Kim, Woo Joo | - |
dc.identifier.doi | 10.1099/jmm.0.070672-0 | - |
dc.identifier.scopusid | 2-s2.0-84908342306 | - |
dc.identifier.wosid | 000347131800019 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICAL MICROBIOLOGY, v.63, pp.1542 - 1551 | - |
dc.relation.isPartOf | JOURNAL OF MEDICAL MICROBIOLOGY | - |
dc.citation.title | JOURNAL OF MEDICAL MICROBIOLOGY | - |
dc.citation.volume | 63 | - |
dc.citation.startPage | 1542 | - |
dc.citation.endPage | 1551 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | POLYMERASE-CHAIN-REACTION | - |
dc.subject.keywordPlus | PCR RIBOTYPE 027 | - |
dc.subject.keywordPlus | BINARY TOXIN | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | PSEUDOMEMBRANOUS COLITIS | - |
dc.subject.keywordPlus | ACINETOBACTER SPP. | - |
dc.subject.keywordPlus | DIARRHEA | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | STRAIN | - |
dc.subject.keywordPlus | SURVEILLANCE | - |
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