Epidemiology and clinical features of toxigenic culture-confirmed hospital-onset Clostridium difficile infection: a multicentre prospective study in tertiary hospitals of South Korea
- Authors
- Han, Sang Hoon; Kim, Heejung; Lee, Kyungwon; Jeong, Su Jin; Park, Ki-Ho; Song, Joon Young; Seo, Yu Bin; Choi, Jun Yong; Woo, Jun Hee; Kim, Woo Joo; Kim, June Myung
- Issue Date
- 11월-2014
- Publisher
- MICROBIOLOGY SOC
- Citation
- JOURNAL OF MEDICAL MICROBIOLOGY, v.63, pp.1542 - 1551
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF MEDICAL MICROBIOLOGY
- Volume
- 63
- Start Page
- 1542
- End Page
- 1551
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/96846
- DOI
- 10.1099/jmm.0.070672-0
- ISSN
- 0022-2615
- Abstract
- Hypervirulent Clostridium difficile strains, most notably BI/NAP1/027, have been increasingly emerging in Western countries as local epidemics. We performed a prospective multicentre observational study from December 2011 to May 2012 to identify recent incidences of toxigenic culture-confirmed hospital-onset C. difficile infections (CD!) and their associated clinical characteristics in South Korea. Patients suspected of having been suffering from CDI more than 48 h after admission and aged >= 20 years were prospectively enrolled and provided loose stool specimens Toxigenic C. difficile culture (anaerobic cultured-toxin A/B/binary gene PCR) and PCR ribotyping were performed in one central laboratory. We enrolled 98 toxigenic cultureconfirmed CDI-infected patients and 250 toxigenic culture-negative participants from three hospitals. The incidence of toxigenic culture-confirmed hospital-onset CU cases was 2.7 per 10 000 patient-days. The percentage of severe CD' cases was relatively low at only 3.1 %. UK ribotype 018 was the predominant type (48.1%). There were no hypervirulent BI/NAP1/027 isolates identified. The independent risk factors for toxigenic culture-confirmed hospital-onset CDI were invasive procedure (odds ratio (OR) 7.3, P=0.003) and past CDI history within 3 months (OR 28.5, P=0.003). In conclusion, the incidence and severity of CDI in our study were not higher than reported in Western countries.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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