Characteristics of platelet indices, neutrophil-to-lymphocyte ratio and erythrocyte sedimentation rate compared with C reactive protein in patients with cerebral infarction: a retrospective analysis of comparing haematological parameters and C reactive protein
- Authors
- Lee, Jong-Han; Kwon, Kyum-Yil; Yoon, Soo-Young; Kim, Hyon-Suk; Lim, Chae Seung
- Issue Date
- 11월-2014
- Publisher
- BMJ PUBLISHING GROUP
- Citation
- BMJ OPEN, v.4, no.11
- Indexed
- SCIE
SCOPUS
- Journal Title
- BMJ OPEN
- Volume
- 4
- Number
- 11
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/96856
- DOI
- 10.1136/bmjopen-2014-006275
- ISSN
- 2044-6055
- Abstract
- Objective: Elevation of C reactive protein (CRP) is one of the major acute-phase responses following ischaemic or haemorrhagic stroke. This study aims to investigate the associations between platelet indices, neutrophil-to-lymphocyte ratio (NLR) and erythrocyte sedimentation rate (ESR) compared with CRP in patients with cerebral infarction. Setting: The clinical data of patients with cerebral infarction were analysed retrospectively. Participants: We analysed, unduplicated, 516 patients with cerebral infarction (mean age 66.2 +/- 12.7, male/female=291/225). Outcome measures: Mean platelet volume (MPV), MPV to platelet count, NLR and ESR were compared with CRP in patients with cerebral infarction in a single institute through Spearman correlation test. Results: There were significant correlations between CRP and MPV (rho=0.088, p=0.045), NLR (rho=0.4, p<0.001) and ESR (rho=0.468, p<0.001) in patients with cerebral infarction. In the male group, NLR (rho=0.398, p<0.001) and ESR (rho=0.502, p<0.001) showed significant correlations with CRP. In the female group, CRP showed significant correlations with MPV (rho=0.17, p=0.011), NLR (rho=0.392, p<0.001) and ESR (rho=0.475, p<0.001). Conclusions: MPV, NLR and ESR showed significant correlation with CRP in patients with cerebral infarction. MPV and NLR are cost-effective and simple parameters that can be attainable by using an automatic haematology analyser. Further well-designed and large-scale prospective studies are warranted to evaluate platelet indices or NLR for monitoring patients with cerebral infarction.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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