Estrogenic activity of a Rhus verniciflua extract and its major components
- Authors
- Sun, Seunghan; Choi, Yun-Ho; Na, Chun-Soo; Lee, Dongho; Yoo, Hye Hyun; Hong, Cheol Yi; Ahn, Byung Yoon; Dong, Mi-Sook
- Issue Date
- Nov-2014
- Publisher
- ELSEVIER
- Keywords
- Rhus verniciflua stokes; Estrogenic activity; Estrogen receptor alpha and beta; Reporter gene assay; Uterotrophic assay
- Citation
- JOURNAL OF FUNCTIONAL FOODS, v.11, pp.250 - 260
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF FUNCTIONAL FOODS
- Volume
- 11
- Start Page
- 250
- End Page
- 260
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/96868
- DOI
- 10.1016/j.jff.2014.09.014
- ISSN
- 1756-4646
- Abstract
- Rhus verniciflua Stokes has been used as a traditional herbal medicine, a food additive, and a material for lacquer in Korea. In this study, hot water extracts of R. verniciflua Stokes xylem (RVE) and purified compounds were examined for estrogenic activity. RVE showed estrogenic activity mediated by estrogen receptors (ER) with a higher binding affinity and activity to ER beta than to ER alpha in ER alpha- or ER beta-transfected cells. It also exhibited estrogenic activity in a uterotrophic assay using rats. All of RVE compounds had high affinity to ER beta compared with ER alpha in reporter gene assay and ER binding assay. Among seven RVE compounds, butin, butein, sulfuretin, and garbanzol had a strong estrogenic activity in ERE-mediated reporter gene assay. Butein and sulfuretin had stronger ER beta binding affinity compared with others. Collectively, these results demonstrate an estrogenic activity of RVE and suggest its potential value for postmenopausal women. (C) 2014 Elsevier Ltd. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
- College of Life Sciences and Biotechnology > Division of Life Sciences > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholar.korea.ac.kr/handle/2021.sw.korea/96868)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.