Meta-analysis of associations between interleukin-10 polymorphisms and susceptibility to pre-eclampsia
- Authors
- Lee, Y. H.; Kim, J. -H.; Song, G. G.
- Issue Date
- Nov-2014
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Pre-eclampsia; Interleukin-10; Polymorphism; Meta-analysis
- Citation
- EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, v.182, pp.202 - 207
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
- Volume
- 182
- Start Page
- 202
- End Page
- 207
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/96932
- DOI
- 10.1016/j.ejogrb.2014.09.030
- ISSN
- 0301-2115
- Abstract
- Objective: To investigate whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to pre-eclampsia. Methods: A meta-analysis was conducted on the associations between IL-10-1082 C/A, -819 C/T and 592 C/A polymorphisms and pre-eclampsia using allele contrast, a recessive model, a dominant model and an additive model. Results: Thirteen groups from 11 papers involving 1534 patients with pre-eclampsia and 2271 controls were considered in the meta-analysis. Meta-analysis of the IL-10-1082 G/A polymorphism in 3500 study subjects revealed no association between pre-eclampsia and the IL-10-1082 G allele [odds ratio (OR) 0.890, 95% confidence interval (CI) 0.729-1.087; p = 0.254]. Stratification by ethnicity indicated an association between the IL-10-1082 G allele and pre-eclampsia in the Iranian groups (OR 1.408,95% CI 1.097-1.807; p = 0.007), but not in the European groups (OR 0.759, 95% CI 0.506-1.136; p = 0.180). Meta-analysis revealed an association between pre-eclampsia and the IL-10-819 C allele in all study subjects (OR 1.296, 95% CI 1.012-1.661; p = 0.040), particularly among the Iranian groups (OR 1.390, 95% CI 1.067-1.811; p = 0.015). Meta-analysis showed no association between pre-eclampsia and the IL-10-592 C allele (OR 1.215,95% CI 0.967-1.527; p = 0.094) in any groups, except for the Iranian groups (OR 1.380,95% CI 1.056-1.805; p = 0.018). However, the associations found in the meta-analysis became non-significant after exclusion of the studies in which the controls showed deviation from Hardy-Weinberg equilibrium. Conclusions: This meta-analysis suggests that IL-10-1082 G/A, -819 C/T and -592 C/A polymorphisms are unlikely to be important in susceptibility to pre-eclampsia. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholar.korea.ac.kr/handle/2021.sw.korea/96932)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.