Antiproliferative Prenylated Xanthones and Benzophenones from the Roots of Cudrania tricuspidata in HSC-T6 Cells
DC Field | Value | Language |
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dc.contributor.author | Jo, Yang Hee | - |
dc.contributor.author | Shin, Bora | - |
dc.contributor.author | Liu, Qing | - |
dc.contributor.author | Lee, Ki Yong | - |
dc.contributor.author | Oh, Dong-Chan | - |
dc.contributor.author | Hwang, Bang Yeon | - |
dc.contributor.author | Lee, Mi Kyeong | - |
dc.date.accessioned | 2021-09-05T03:48:18Z | - |
dc.date.available | 2021-09-05T03:48:18Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-11 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/97035 | - |
dc.description.abstract | Four new prenylated xanthones, cudracuspixanthones A-D (1-4), two new prenylated benzophenones, cudracuspiphenones A (5) and B (6), and 11 known xanthones (7-17) were isolated from the roots of Cudrania tricuspidata. The absolute configurations of compounds 2-4 were deduced by the comparison of the calculated optical rotation values with the measured data. Compounds 1, 5, and 6 showed moderate antiproliferative activity on HSC-T6 cells with IC50 values of 9.7, 3.3, and 7.1 mu M, respectively. Compounds 2-4, 10, and 14-16 had weaker activity. Flow cytometric analysis suggested that compounds 1 and 5 inhibited HSC-T6 cell proliferation in part by inducing apoptosis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | ISOPRENYLATED XANTHONES | - |
dc.subject | MORACEAE PLANTS | - |
dc.subject | BARK | - |
dc.subject | CONSTITUENTS | - |
dc.subject | COMPONENTS | - |
dc.subject | INHIBITORS | - |
dc.title | Antiproliferative Prenylated Xanthones and Benzophenones from the Roots of Cudrania tricuspidata in HSC-T6 Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Ki Yong | - |
dc.identifier.doi | 10.1021/np5002797 | - |
dc.identifier.scopusid | 2-s2.0-84913553471 | - |
dc.identifier.wosid | 000345472100005 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NATURAL PRODUCTS, v.77, no.11, pp.2361 - 2366 | - |
dc.relation.isPartOf | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.title | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.volume | 77 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2361 | - |
dc.citation.endPage | 2366 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ISOPRENYLATED XANTHONES | - |
dc.subject.keywordPlus | MORACEAE PLANTS | - |
dc.subject.keywordPlus | BARK | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | COMPONENTS | - |
dc.subject.keywordPlus | INHIBITORS | - |
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