Antiproliferative Prenylated Xanthones and Benzophenones from the Roots of Cudrania tricuspidata in HSC-T6 Cells
- Authors
- Jo, Yang Hee; Shin, Bora; Liu, Qing; Lee, Ki Yong; Oh, Dong-Chan; Hwang, Bang Yeon; Lee, Mi Kyeong
- Issue Date
- 11월-2014
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.77, no.11, pp.2361 - 2366
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 77
- Number
- 11
- Start Page
- 2361
- End Page
- 2366
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/97035
- DOI
- 10.1021/np5002797
- ISSN
- 0163-3864
- Abstract
- Four new prenylated xanthones, cudracuspixanthones A-D (1-4), two new prenylated benzophenones, cudracuspiphenones A (5) and B (6), and 11 known xanthones (7-17) were isolated from the roots of Cudrania tricuspidata. The absolute configurations of compounds 2-4 were deduced by the comparison of the calculated optical rotation values with the measured data. Compounds 1, 5, and 6 showed moderate antiproliferative activity on HSC-T6 cells with IC50 values of 9.7, 3.3, and 7.1 mu M, respectively. Compounds 2-4, 10, and 14-16 had weaker activity. Flow cytometric analysis suggested that compounds 1 and 5 inhibited HSC-T6 cell proliferation in part by inducing apoptosis.
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