Are Sensory TRP Channels Biological Alarms for Lipid Peroxidation?
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Seung-In | - |
dc.contributor.author | Yoo, Sungjae | - |
dc.contributor.author | Lim, Ji Yeon | - |
dc.contributor.author | Hwang, Sun Wook | - |
dc.date.accessioned | 2021-09-05T05:40:43Z | - |
dc.date.available | 2021-09-05T05:40:43Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-09 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/97517 | - |
dc.description.abstract | Oxidative stress induces numerous biological problems. Lipid oxidation and peroxidation appear to be important steps by which exposure to oxidative stress leads the body to a disease state. For its protection, the body has evolved to respond to and eliminate peroxidation products through the acquisition of binding proteins, reducing and conjugating enzymes, and excretion systems. During the past decade, researchers have identified a group of ion channel molecules that are activated by oxidized lipids: transient receptor potential (TRP) channels expressed in sensory neurons. These ion channels are fundamentally detectors and signal converters for body-damaging environments such as heat and cold temperatures, mechanical attacks, and potentially toxic substances. When messages initiated by TRP activation arrive at the brain, we perceive pain, which results in our preparing defensive responses. Excessive activation of the sensory neuronal TRP channels upon prolonged stimulations sometimes deteriorates the inflammatory state of damaged tissues by promoting neuropeptide release from expresser neurons. These same paradigms may also work for pathologic changes in the internal lipid environment upon exposure to oxidative stress. Here, we provide an overview of the role of TRP channels and oxidized lipid connections during abnormally increased oxidative signaling, and consider the sensory mechanism of TRP detection as an alert system. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | POLYUNSATURATED FATTY-ACIDS | - |
dc.subject | RECEPTOR POTENTIAL A1 | - |
dc.subject | ROOT GANGLION NEURONS | - |
dc.subject | ION-CHANNEL | - |
dc.subject | NEUROGENIC INFLAMMATION | - |
dc.subject | COVALENT MODIFICATION | - |
dc.subject | CAPSAICIN RECEPTOR | - |
dc.subject | DIRECT ACTIVATION | - |
dc.subject | NOCICEPTIVE NEURONS | - |
dc.subject | URINARY METABOLITE | - |
dc.title | Are Sensory TRP Channels Biological Alarms for Lipid Peroxidation? | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hwang, Sun Wook | - |
dc.identifier.doi | 10.3390/ijms150916430 | - |
dc.identifier.scopusid | 2-s2.0-84907831153 | - |
dc.identifier.wosid | 000343109700091 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.15, no.9, pp.16430 - 16457 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 15 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 16430 | - |
dc.citation.endPage | 16457 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | POLYUNSATURATED FATTY-ACIDS | - |
dc.subject.keywordPlus | RECEPTOR POTENTIAL A1 | - |
dc.subject.keywordPlus | ROOT GANGLION NEURONS | - |
dc.subject.keywordPlus | ION-CHANNEL | - |
dc.subject.keywordPlus | NEUROGENIC INFLAMMATION | - |
dc.subject.keywordPlus | COVALENT MODIFICATION | - |
dc.subject.keywordPlus | CAPSAICIN RECEPTOR | - |
dc.subject.keywordPlus | DIRECT ACTIVATION | - |
dc.subject.keywordPlus | NOCICEPTIVE NEURONS | - |
dc.subject.keywordPlus | URINARY METABOLITE | - |
dc.subject.keywordAuthor | sensory TRP ion channels | - |
dc.subject.keywordAuthor | pain | - |
dc.subject.keywordAuthor | lipid peroxidation | - |
dc.subject.keywordAuthor | oxidative stress | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.